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Tbio
SEC61B
Protein transport protein Sec61 subunit beta

Protein Summary
Description
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223641
  • ENSP00000223641
  • ENSG00000106803
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
histone modification site profile
0.92
ligand (protein) perturbation
0.83
cell type or tissue
0.77
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
60.4
2
2
0
1.1
51.4
smoking status measurement
2
2
1
1
34.7
atrophic macular degeneration
1
1
0
1.1
7.6
1
1
0
1.1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
60.4
0
1.1
51.4
smoking status measurement
1
1
34.7
atrophic macular degeneration
0
1.1
7.6
0
1.1
7.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon beta subunit
VGNC:4858
747589
Macaque
Sec61 translocon beta subunit
717815
Mouse
MGI:3642323
101055909
Rat
RGD:1304997
298068
Dog
Sec61 translocon beta subunit
VGNC:49616
404018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon beta subunit
Macaque
Sec61 translocon beta subunit
Mouse
Rat
Dog
Sec61 translocon beta subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P60468-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Protein-Protein Interactions (271)
1 – 10 of 271
COPG2
Tbio
Novelty:  0.06126837
p_int:  0.992637493
p_ni:  0.007362507
Data Source:  BioPlex
COPB1
Tbio
Novelty:  0.0078407
p_int:  0.952425224
p_ni:  0.047574776
Score:  0.163
Data Source:  BioPlex,STRINGDB
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.938000634
p_ni:  0.061999364
p_wrong:  2e-9
Data Source:  BioPlex
COPA
Tbio
Novelty:  0.02712824
p_int:  0.844624867
p_ni:  0.155375133
Data Source:  BioPlex
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC61G
Tbio
Novelty:  0.11375671
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.998
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.997
Data Source:  STRINGDB
RPS9
Tbio
Novelty:  0.01329701
Score:  0.997
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.997
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.89

PubMed score by year
PubTator Score  19.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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