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Tdark
KRTAP10-6
Keratin-associated protein 10-6

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400368
  • ENSP00000383219
  • ENSG00000188155

Symbol
  • KAP10.6
  • KAP18-6
  • KRTAP10.6
  • KRTAP18-6
  • KRTAP18.6
  • KAP10.6
  • KAP18.6
  • KRTAP18-6
  • KRTAP18.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.48
cell line
0.44
cellular component
0.25
transcription factor
0.22
microRNA
0.19


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P60371-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (72)
1 – 10 of 72
ODF3L1
Tdark
Novelty: 9.03484782
Score: 0.556
Data Source: STRINGDB
KRTAP26-1
Tdark
Novelty: 0.48053029
Score: 0.526
Data Source: STRINGDB
KRTAP27-1
Tdark
Novelty: 0.72484342
Score: 0.526
Data Source: STRINGDB
KRTAP1-4
Tdark
Novelty: 0.44744505
Score: 0.514
Data Source: STRINGDB
KRTAP5-9
Tdark
Novelty: 0.13336736
Score: 0.504
Data Source: STRINGDB
KRTAP5-11
Tdark
Novelty: 51.19366197
Score: 0.502
Data Source: STRINGDB
KRTAP12-1
Tdark
Novelty: 0.59243755
Score: 0.5
Data Source: STRINGDB
KRTAP19-4
Tdark
Novelty: 217
Score: 0.5
Data Source: STRINGDB
KRTAP4-5
Tbio
Novelty: 3.61629007
Score: 0.497
Data Source: STRINGDB
KRTAP20-1
Tdark
Novelty: 0.5308345
Score: 0.492
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.06

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer