Tbio NANOS3 Nanos homolog 3

Protein Summary

Description

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Uniprot Accession IDs

• P60323
• Q495E5
• NOS-3

Gene Name

• NANOS3

Ensembl ID

• ENST00000339133
• ENSP00000341992
• ENSG00000187556
• ENST00000397555
• ENSP00000380687

Symbol

• NOS3
• NOS3
• NANOS1L
• ZC2HC12C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.67
cell type or tissue	0.66
tissue	0.64
PubMedID	0.58
cellular component	0.54

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Nanos Homolog 3

DTO Classes

Protein / Enzyme / Nuclease / Nanos Homolog 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.59   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0