You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TPI1
Triosephosphate isomerase

Protein Classes
Protein Summary
Description
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229270
  • ENSP00000229270
  • ENSG00000111669
  • ENST00000396705
  • ENSP00000379933
  • ENST00000488464
  • ENSP00000475620
  • ENST00000535434
  • ENSP00000443599
  • ENST00000613953
  • ENSP00000484435

Symbol
  • TPI
  • TIM
  • TPI
  • TPID
  • HEL-S-49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein complex
0.98
virus perturbation
0.94
interacting protein
0.92
kinase perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.62   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.62   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triosephosphate isomerase 1
VGNC:13481
451799
Mouse
MGI:98797
21991
Dog
triosephosphate isomerase 1
VGNC:47740
477711
Horse
triosephosphate isomerase 1
VGNC:24432
100052671
Cow
triosephosphate isomerase 1
VGNC:36250
281543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triosephosphate isomerase 1
Mouse
Dog
triosephosphate isomerase 1
Horse
triosephosphate isomerase 1
Cow
triosephosphate isomerase 1
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60174-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (486)
1 – 10 of 486
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.999
Data Source: STRINGDB
PGK1
Tchem
Family: Kinase
Novelty: 0.00113494
Score: 0.999
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.999
Data Source: STRINGDB
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
Score: 0.996
Data Source: STRINGDB
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
Score: 0.995
Data Source: STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
Score: 0.994
Data Source: STRINGDB
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
Score: 0.99
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
Score: 0.984
Data Source: STRINGDB
ALDOC
Tbio
Family: Enzyme
Novelty: 0.01552954
Score: 0.983
Data Source: STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.00856695
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  1333.62

PubMed score by year
PubTator Score  801.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: