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Tbio
TPI1
Triosephosphate isomerase

Protein Summary
Description
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229270
  • ENSP00000229270
  • ENSG00000111669
  • ENST00000396705
  • ENSP00000379933
  • ENST00000488464
  • ENSP00000475620
  • ENST00000535434
  • ENSP00000443599
  • ENST00000613953
  • ENSP00000484435

Symbol
  • TPI
  • TIM
  • TPI
  • TPID
  • HEL-S-49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein complex
0.98
virus perturbation
0.94
interacting protein
0.92
kinase perturbation
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1352.69   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1352.69   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (486)
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.999
Data Source:  STRINGDB
PGK1
Tchem
Family:  Kinase
Novelty:  0.00113494
Score:  0.999
Data Source:  STRINGDB
GAPDH
Tchem
Family:  Enzyme
Novelty:  0.00005849
Score:  0.999
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.996
Data Source:  STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
Score:  0.995
Data Source:  STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
Score:  0.994
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.99
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.984
Data Source:  STRINGDB
ALDOC
Tbio
Family:  Enzyme
Novelty:  0.01552954
Score:  0.983
Data Source:  STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
oleic acid measurement
1
1
1
84
fatty acid measurement
1
1
1
84
docosapentaenoic acid measurement
1
1
1
84
arachidonic acid measurement
1
1
1
84
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
oleic acid measurement
1
84
fatty acid measurement
1
84
docosapentaenoic acid measurement
1
84
arachidonic acid measurement
1
84
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triosephosphate isomerase 1
VGNC:13481
451799
Mouse
MGI:98797
21991
Dog
triosephosphate isomerase 1
VGNC:47740
477711
Horse
triosephosphate isomerase 1
VGNC:24432
100052671
Cow
triosephosphate isomerase 1
VGNC:36250
281543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triosephosphate isomerase 1
Mouse
Dog
triosephosphate isomerase 1
Horse
triosephosphate isomerase 1
Cow
triosephosphate isomerase 1
Publication Statistics
PubMed Score 1352.69
PubMed score by year
PubTator Score 801.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title