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Tbio
SEC61G
Protein transport protein Sec61 subunit gamma

Protein Summary
Description
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352861
  • ENSP00000341538
  • ENSG00000132432
  • ENST00000395535
  • ENSP00000378906
  • ENST00000415949
  • ENSP00000388337
  • ENST00000450622
  • ENSP00000409884

Symbol
  • SSS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
disease perturbation
0.83
transcription factor binding site profile
0.78
interacting protein
0.71
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (263)
RPL30
Tbio
Novelty:  0.0134194
Score:  0.999
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.999
Data Source:  Reactome,STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.998
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.998
Data Source:  STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.998
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.998
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.998
Data Source:  STRINGDB
RPS25
Tbio
Novelty:  0.02812798
Score:  0.998
Data Source:  STRINGDB
RPL39
Tbio
Novelty:  0.0307397
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glioblastoma multiforme
3
1
0
1.7
31.2
4
1
0
1.4
31.2
4
1
0
1.4
28
age at onset
1
1
0
1.7
13.8
cognitive function measurement
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glioblastoma multiforme
0
1.7
31.2
0
1.4
31.2
0
1.4
28
age at onset
0
1.7
13.8
cognitive function measurement
1
2.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon gamma subunit
VGNC:4503
387278
Mouse
MGI:1202066
20335
Rat
RGD:1596170
689134
Dog
Sec61 translocon gamma subunit
VGNC:49617
404017
Horse
Sec61 translocon gamma subunit
VGNC:49116
100629979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon gamma subunit
Mouse
Rat
Dog
Sec61 translocon gamma subunit
Horse
Sec61 translocon gamma subunit
Publication Statistics
PubMed Score 12.52
PubMed score by year
PubTator Score 3.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title