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Tchem
CD81
CD81 antigen

Protein Summary
Description
May be involved in the acrosome reaction (By similarity). May play an important role in the regulation of lymphoma cell growth (PubMed:1695320, PubMed:2398277). (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene regi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263645
  • ENSP00000263645
  • ENSG00000110651

Symbol
  • TAPA1
  • TSPAN28
  • S5.7
  • CVID6
  • TAPA1
  • TSPAN28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
biological process
0.9
biological term
0.89
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.94   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 1162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.94   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 1162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (144)
CD19
Tclin
Novelty:  0.0001816
Score:  0.987
Data Source:  Reactome,STRINGDB
IFITM1
Tbio
Novelty:  0.00441449
Score:  0.975
Data Source:  Reactome,STRINGDB
CR2
Tbio
Novelty:  0.00086638
Score:  0.975
Data Source:  Reactome,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.97
Data Source:  STRINGDB
IGSF8
Tbio
Novelty:  0.03016623
Score:  0.964
Data Source:  STRINGDB
ITGA4
Tclin
Novelty:  0.00197607
Score:  0.961
Data Source:  STRINGDB
PTGFRN
Tbio
Novelty:  0.02271483
Score:  0.961
Data Source:  STRINGDB
CLDN1
Tbio
Novelty:  0.00505039
Score:  0.935
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.93
Data Source:  Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.842
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Complement cascade
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Complement cascade
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
2
127
13.2
95.5
QT interval
7
6
2
2.8
94.4
T wave morphology measurement
3
1
3
85.4
mean corpuscular hemoglobin concentration
1
1
1
81.4
basophil count
2
2
2
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
127
13.2
95.5
QT interval
2
2.8
94.4
T wave morphology measurement
3
85.4
mean corpuscular hemoglobin concentration
1
81.4
basophil count
2
81
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD81 molecule
VGNC:11288
449635
Macaque
CD81 molecule
704961
Mouse
MGI:1096398
12520
Rat
RGD:2315
25621
Dog
CD81 molecule
VGNC:49705
611606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD81 molecule
Macaque
CD81 molecule
Mouse
Rat
Dog
CD81 molecule
Publication Statistics
PubMed Score 937.94
PubMed score by year
PubTator Score 423.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title