Protein Summary
May be involved in the acrosome reaction (By similarity). May play an important role in the regulation of lymphoma cell growth (PubMed:1695320, PubMed:2398277). (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene regi ...more
- ENST00000263645
- ENSP00000263645
- ENSG00000110651
- TAPA1
- TSPAN28
- S5.7
- CVID6
- TAPA1
- TSPAN28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.99 | ||
biological process | 0.9 | ||
biological term | 0.89 | ||
virus perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 937.94 (req: < 5)
Gene RIFs: 142 (req: <= 3)
Antibodies: 1162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 937.94 (req: >= 5)
Gene RIFs: 142 (req: > 3)
Antibodies: 1162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (144)
Nearest Tclin Targets
Pathways (14)
Reactome (6)
KEGG (3)
PathwayCommons (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Complement cascade | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (4)
Components (8)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 2 | 2 | 127 | 13.2 | 95.5 | ||||
QT interval | 7 | 6 | 2 | 2.8 | 94.4 | ||||
T wave morphology measurement | 3 | 1 | 3 | 85.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 81.4 | |||||
basophil count | 2 | 2 | 2 | 81 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 127 | 13.2 | 95.5 | ||||
QT interval | 2 | 2.8 | 94.4 | ||||
T wave morphology measurement | 3 | 85.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 81.4 | |||||
basophil count | 2 | 81 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD81 molecule | VGNC:11288 | 449635 | |||||
Macaque | CD81 molecule | 704961 | ||||||
Mouse | MGI:1096398 | 12520 | ||||||
Rat | RGD:2315 | 25621 | ||||||
Dog | CD81 molecule | VGNC:49705 | 611606 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD81 molecule | |||||
Macaque | CD81 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD81 molecule | |||||
Publication Statistics
PubMed Score 937.94
PubMed score by year
PubTator Score 423.64
PubTator score by year
Related Publications
Text Mined References (207)
GeneRif Annotations (142)
Items per page:
0 of 0
PMID | Year | Title |
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