Protein Summary
May be involved in the acrosome reaction (By similarity). May play an important role in the regulation of lymphoma cell growth (PubMed:1695320, PubMed:2398277). (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene regi ...more
- ENST00000263645
- ENSP00000263645
- ENSG00000110651
- TAPA1
- TSPAN28
- S5.7
- CVID6
- TAPA1
- TSPAN28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.99 | ||
biological process | 0.9 | ||
biological term | 0.89 | ||
virus perturbation | 0.88 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 907.43 (req: < 5)
Gene RIFs: 142 (req: <= 3)
Antibodies: 1162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 907.43 (req: >= 5)
Gene RIFs: 142 (req: > 3)
Antibodies: 1162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD81 molecule | VGNC:11288 | 449635 | |||||
Macaque | CD81 molecule | 704961 | ||||||
Mouse | MGI:1096398 | 12520 | ||||||
Rat | RGD:2315 | 25621 | ||||||
Dog | CD81 molecule | VGNC:49705 | 611606 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD81 molecule | |||||
Macaque | CD81 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD81 molecule | |||||
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (14)
Reactome (6)
KEGG (3)
PathwayCommons (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Complement cascade | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Innate Immune System | ||||
Gene Ontology Terms (31)
Functions (4)
Components (8)
Processes (19)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Protein-Protein Interactions (144)
1 – 10 of 144
CD19
Novelty: 0.0001816
Score: 0.987
Data Source: Reactome,STRINGDB
IFITM1
Novelty: 0.00441449
Score: 0.975
Data Source: Reactome,STRINGDB
CR2
Novelty: 0.00086638
Score: 0.975
Data Source: Reactome,STRINGDB
ITGB1
Novelty: 0.00055626
Score: 0.97
Data Source: STRINGDB
IGSF8
Novelty: 0.03016623
Score: 0.964
Data Source: STRINGDB
ITGA4
Novelty: 0.00197607
Score: 0.961
Data Source: STRINGDB
PTGFRN
Novelty: 0.02271483
Score: 0.961
Data Source: STRINGDB
CLDN1
Novelty: 0.00505039
Score: 0.935
Data Source: STRINGDB
C3
Novelty: 0.00019115
Score: 0.93
Data Source: Reactome,STRINGDB
TSG101
Novelty: 0.00211746
Score: 0.842
Data Source: STRINGDB
Publication Statistics
PubMed Score 907.43
PubMed score by year
PubTator Score 423.64
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword