ANAPC15
Anaphase-promoting complex subunit 15
Protein Summary
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
- ENST00000227618
- ENSP00000227618
- ENSG00000110200
- ENST00000535234
- ENSP00000446412
- ENST00000535503
- ENSP00000443383
- ENST00000538393
- ENSP00000440002
- ENST00000538919
- ENSP00000440983
- ENST00000542531
- ENSP00000443911
- ENST00000543587
- ENSP00000439403
- ENST00000545680
- ENSP00000443645
- ENST00000545944
- ENSP00000446383
- C11orf51
- APC15
- HSPC020
- C11orf51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
virus perturbation | 0.72 | ||
cell line | 0.66 | ||
tissue | 0.65 | ||
cell type or tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.39 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 32 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.39 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 32 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0