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Tdark
ANAPC15
Anaphase-promoting complex subunit 15

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227618
  • ENSP00000227618
  • ENSG00000110200
  • ENST00000535234
  • ENSP00000446412
  • ENST00000535503
  • ENSP00000443383
  • ENST00000538393
  • ENSP00000440002
  • ENST00000538919
  • ENSP00000440983
  • ENST00000542531
  • ENSP00000443911
  • ENST00000543587
  • ENSP00000439403
  • ENST00000545680
  • ENSP00000443645
  • ENST00000545944
  • ENSP00000446383

Symbol
  • C11orf51
  • APC15
  • HSPC020
  • C11orf51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.72
cell line
0.66
tissue
0.65
cell type or tissue
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
anaphase promoting complex subunit 15
718333
Mouse
MGI:1922680
75430
Rat
RGD:1311634
293155
Dog
anaphase promoting complex subunit 15
VGNC:37847
476817
Horse
anaphase promoting complex subunit 15
VGNC:15291
100066106
Species
Name
OMA
EggNOG
Inparanoid
Macaque
anaphase promoting complex subunit 15
Mouse
Rat
Dog
anaphase promoting complex subunit 15
Horse
anaphase promoting complex subunit 15
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60006-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
LIFEdb
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (135)
1 – 10 of 135
ANAPC2
Tbio
Family: Enzyme
Novelty: 0.19812984
Score: 0.999
Data Source: STRINGDB
ANAPC4
Tbio
Family: Enzyme
Novelty: 0.28937094
Score: 0.999
Data Source: STRINGDB
ANAPC16
Tdark
Family: Enzyme
Novelty: 0.06353035
Score: 0.997
Data Source: STRINGDB
ANAPC10
Tbio
Family: Enzyme
Novelty: 0.02993125
Score: 0.996
Data Source: STRINGDB
ANAPC13
Tbio
Family: Enzyme
Novelty: 0.06125489
Score: 0.995
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.994
Data Source: STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
Score: 0.994
Data Source: STRINGDB
FZR1
Tbio
Novelty: 0.01599606
Score: 0.993
Data Source: STRINGDB
ANAPC11
Tbio
Family: Enzyme
Novelty: 0.02976518
Score: 0.993
Data Source: STRINGDB
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.51

PubMed score by year
PubTator Score  3.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer