ANAPC15
Anaphase-promoting complex subunit 15
Protein Summary
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
- ENST00000227618
- ENSP00000227618
- ENSG00000110200
- ENST00000535234
- ENSP00000446412
- ENST00000535503
- ENSP00000443383
- ENST00000538393
- ENSP00000440002
- ENST00000538919
- ENSP00000440983
- ENST00000542531
- ENSP00000443911
- ENST00000543587
- ENSP00000439403
- ENST00000545680
- ENSP00000443645
- ENST00000545944
- ENSP00000446383
- C11orf51
- APC15
- HSPC020
- C11orf51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
virus perturbation | 0.72 | ||
cell line | 0.66 | ||
tissue | 0.65 | ||
cell type or tissue | 0.56 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.51 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 32 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.51 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 32 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | anaphase promoting complex subunit 15 | 718333 | ||||||
Mouse | MGI:1922680 | 75430 | ||||||
Rat | RGD:1311634 | 293155 | ||||||
Dog | anaphase promoting complex subunit 15 | VGNC:37847 | 476817 | |||||
Horse | anaphase promoting complex subunit 15 | VGNC:15291 | 100066106 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | anaphase promoting complex subunit 15 | |||||
Mouse | ||||||
Rat | ||||||
Dog | anaphase promoting complex subunit 15 | |||||
Horse | anaphase promoting complex subunit 15 | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (33)
Reactome (33)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 33
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | APC-Cdc20 mediated degradation of Nek2A | ||||
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Reactome | APC/C:Cdc20 mediated degradation of Securin | ||||
Reactome | APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
APC-Cdc20 mediated degradation of Nek2A | ||||
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of Cyclin B | ||||
APC/C:Cdc20 mediated degradation of Securin | ||||
APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Gene Ontology Terms (9)
Components (4)
Processes (5)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | LIFEdb | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (135)
1 – 10 of 135
ANAPC2
Family: Enzyme
Novelty: 0.19812984
Score: 0.999
Data Source: STRINGDB
ANAPC4
Family: Enzyme
Novelty: 0.28937094
Score: 0.999
Data Source: STRINGDB
ANAPC16
Family: Enzyme
Novelty: 0.06353035
Score: 0.997
Data Source: STRINGDB
ANAPC10
Family: Enzyme
Novelty: 0.02993125
Score: 0.996
Data Source: STRINGDB
ANAPC13
Family: Enzyme
Novelty: 0.06125489
Score: 0.995
Data Source: STRINGDB
CDC20
Novelty: 0.00197887
Score: 0.994
Data Source: STRINGDB
ANAPC5
Family: Enzyme
Novelty: 0.02102572
Score: 0.994
Data Source: STRINGDB
FZR1
Novelty: 0.01599606
Score: 0.993
Data Source: STRINGDB
ANAPC11
Family: Enzyme
Novelty: 0.02976518
Score: 0.993
Data Source: STRINGDB
CDC26
Family: Enzyme
Novelty: 0.07456358
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score 5.51
PubMed score by year
PubTator Score 3.11
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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