DNAJB13
DnaJ homolog subfamily B member 13
Protein Summary
Plays a role in the formation of the central complex of ciliary and flagellar axonemes. This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. [provided by RefSeq, Apr 2017]
- ENST00000339764
- ENSP00000344431
- ENSG00000187726
- ENST00000537753
- ENSP00000439711
- ENST00000543947
- ENSP00000438576
- TSARG3
- TSARG6
- CILD34
- TSARG5
- TSARG6
- RSPH16A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
cell line | 0.66 | ||
protein domain | 0.58 | ||
cell type or tissue | 0.56 | ||
tissue sample | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.24 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.24 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0