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Tbio
LILRA4
Leukocyte immunoglobulin-like receptor subfamily A member 4

Protein Summary
Description
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). This gene encodes an immunoglobulin-like cell surface protein that is expres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291759
  • ENSP00000291759
  • ENSG00000239961
  • ENST00000613813
  • ENSP00000479979
  • ENSG00000277092
  • ENST00000616790
  • ENSP00000483846
  • ENSG00000274185
  • ENST00000619832
  • ENSP00000481073
  • ENSG00000276798

Symbol
  • ILT7
  • ILT7
  • CD85g
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.72
kinase perturbation
0.66
protein domain
0.58
tissue sample
0.57
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.33   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.33   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (105)
1 – 10 of 105
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.92
Data Source:  STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
Score:  0.914
Data Source:  STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
Score:  0.91
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.908
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
GWAS Traits (63)
Items per page:
1 – 5 of 63
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
10
25
99
high density lipoprotein cholesterol measurement
12
10
25
99
high density lipoprotein cholesterol measurement
12
10
25
99
apolipoprotein A 1 measurement
2
5
5
97.6
apolipoprotein A 1 measurement
2
5
5
97.6
Items per page:
1 – 5 of 63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
25
99
high density lipoprotein cholesterol measurement
25
99
high density lipoprotein cholesterol measurement
25
99
apolipoprotein A 1 measurement
5
97.6
apolipoprotein A 1 measurement
5
97.6
Find similar targets by:
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukocyte immunoglobulin like receptor A4
VGNC:11158
449639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukocyte immunoglobulin like receptor A4
Publication Statistics
PubMed Score 12.33
PubMed score by year
PubTator Score 12.71
PubTator score by year