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Tbio
DEFB131A
Beta-defensin 131A

Protein Summary
Description
Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771). Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 4p16. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334879
  • ENSP00000335538
  • ENSG00000186146

Symbol
  • DEFB131
  • DEFB31
  • DEFB-31
  • DEFB131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
DEFB113
Tdark
Novelty:  0.54376643
Score:  0.905
Data Source:  STRINGDB
DEFB115
Tdark
Novelty:  0.51464209
Score:  0.904
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.904
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.904
Data Source:  STRINGDB
DEFB118
Tbio
Novelty:  0.14992977
Score:  0.904
Data Source:  STRINGDB
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.904
Data Source:  STRINGDB
DEFB110
Tdark
Novelty:  0.49548192
Score:  0.903
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.903
Data Source:  STRINGDB
DEFB121
Tdark
Novelty:  2.72797456
Score:  0.903
Data Source:  STRINGDB
DEFB112
Tdark
Novelty:  0.29597011
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
5
5
98.5
opioid use disorder
2
1
2
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
98.5
opioid use disorder
2
4.8
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 0.52
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title