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Tdark
SELENOV
Selenoprotein V

Protein Summary
Description
May be involved in a redox-related process. This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335426
  • ENSP00000333956
  • ENSG00000186838

Symbol
  • SELV
  • SELV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein V
736601
Cow
selenoprotein V
VGNC:52246
615288
Pig
selenoprotein V
100307053
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein V
Cow
selenoprotein V
Pig
selenoprotein V
Pathways (94)
Items per page:
1 – 5 of 94
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
Name
Explore in Pharos
Explore in Source
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (42)
1 – 10 of 42
SELENOT
Tbio
Novelty:  0.02480242
Score:  0.877
Data Source:  STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
Score:  0.835
Data Source:  STRINGDB
SELENOK
Tbio
Novelty:  0.02182816
Score:  0.805
Data Source:  STRINGDB
SELENOH
Tbio
Novelty:  0.02421467
Score:  0.788
Data Source:  STRINGDB
SELENOS
Tbio
Novelty:  0.01108715
Score:  0.783
Data Source:  STRINGDB
SELENON
Tbio
Novelty:  0.01018
Score:  0.78
Data Source:  STRINGDB
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
Score:  0.769
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.747
Data Source:  STRINGDB
MSRB1
Tbio
Family:  Enzyme
Novelty:  0.01677161
Score:  0.734
Data Source:  STRINGDB
GPX4
Tbio
Family:  Enzyme
Novelty:  0.00188213
Score:  0.716
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.07

PubMed score by year
PubTator Score  7.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer