Tdark GPX6 Glutathione peroxidase 6

Protein Summary

Description

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• P59796
• Q4PJ17
• GPx-6

Gene Name

• GPX6

Ensembl ID

• ENST00000361902
• ENSP00000354581
• ENSG00000198704

Symbol

• GPX5p
• GPXP3
• GPx-6
• GSHPx-6
• dJ1186N24
• dJ1186N24.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.59
gene perturbation	0.58
protein domain	0.58
microRNA	0.55
tissue	0.52

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.34   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.34   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (89)

Explore Interacting Targets

1 – 10 of 89

• See Interactions on String-DB

SOD1

Tchem

Family:  Enzyme

Novelty:  0.00039653

Score:  0.966

Data Source:  STRINGDB

SOD2

Tbio

Family:  Enzyme

Novelty:  0.00084288

Score:  0.961

Data Source:  STRINGDB

SOD3

Tbio

Family:  Enzyme

Novelty:  0.0015758

Score:  0.955

Data Source:  STRINGDB

GSS

Tbio

Family:  Enzyme

Novelty:  0.03002278

Score:  0.944

Data Source:  STRINGDB

ALOX5

Tclin

Family:  Enzyme

Novelty:  0.00062988

Score:  0.909

Data Source:  STRINGDB

CAT

Tbio

Family:  Enzyme

Novelty:  0.00181888

Score:  0.88

Data Source:  STRINGDB

GSR

Tclin

Family:  Enzyme

Novelty:  0.00040107

Score:  0.869

Data Source:  STRINGDB

GSTM3

Tbio

Family:  Enzyme

Novelty:  0.0078192

Score:  0.866

Data Source:  STRINGDB

GSTM2

Tchem

Family:  Enzyme

Novelty:  0.00334543

Score:  0.866

Data Source:  STRINGDB

HPGDS

Tchem

Family:  Enzyme

Novelty:  0.00019629

Score:  0.826

Data Source:  STRINGDB

Pathways (48)

Reactome (3)

KEGG (4)

PathwayCommons (1)

WikiPathways (40)

Cellular responses to external stimuli (R-HSA-8953897)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
glutathione peroxidase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

GWAS Traits (20)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	2	3	0	1.1	89.1
BMI-adjusted hip circumference	EFO_0008039	1	3	3		67.4
unipolar depression	EFO_0003761	2	2	2		66.6
autism spectrum disorder	EFO_0003756	1	1	0	1.1	64.4
body height	EFO_0004339	1	1	1		58.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	0	1.1	89.1
BMI-adjusted hip circumference	EFO_0008039	3		67.4
unipolar depression	EFO_0003761	2		66.6
autism spectrum disorder	EFO_0003756	0	1.1	64.4
body height	EFO_0004339	1		58.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Secreted
Selenocysteine
Signal

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
anti-merkel cell virus antibody measurement
autism spectrum disorder
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
cognitive function measurement
feeling miserable measurement
HbA1c measurement
lung carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutathione peroxidase 6	VGNC:2850	471920
Macaque	glutathione peroxidase 6		100286832
Mouse	glutathione peroxidase 6	MGI:1922762	75512
Rat	glutathione peroxidase 6	RGD:628789	259233

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutathione peroxidase 6
Macaque	glutathione peroxidase 6
Mouse	glutathione peroxidase 6
Rat	glutathione peroxidase 6

Publication Statistics

PubMed Score 35.34

PubMed score by year

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PubTator Score 4.13

PubTator score by year

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