Protein Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine ...more
- ENST00000361902
- ENSP00000354581
- ENSG00000198704
- GPX5p
- GPXP3
- GPx-6
- GSHPx-6
- dJ1186N24
- dJ1186N24.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.59 | ||
gene perturbation | 0.58 | ||
protein domain | 0.58 | ||
microRNA | 0.55 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.34 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 41 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.34 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 41 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (48)
Reactome (3)
KEGG (4)
PathwayCommons (1)
WikiPathways (40)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.1 | 89.1 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 67.4 | |||||
2 | 2 | 2 | 66.6 | ||||||
1 | 1 | 0 | 1.1 | 64.4 | |||||
body height | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 89.1 | |||||
BMI-adjusted hip circumference | 3 | 67.4 | |||||
2 | 66.6 | ||||||
0 | 1.1 | 64.4 | |||||
body height | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 6 | VGNC:2850 | 471920 | |||||
Macaque | glutathione peroxidase 6 | 100286832 | ||||||
Mouse | MGI:1922762 | 75512 | ||||||
Rat | RGD:628789 | 259233 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 6 | |||||
Macaque | glutathione peroxidase 6 | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 35.34
PubMed score by year
PubTator Score 4.13
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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