Tbio GPX6 Glutathione peroxidase 6

Protein Summary

Description

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• P59796
• Q4PJ17
• GPx-6

Gene Name

• GPX6

Ensembl ID

• ENST00000361902
• ENSP00000354581
• ENSG00000198704

Symbol

• GPX5p
• GPXP3
• GPx-6
• GSHPx-6
• dJ1186N24
• dJ1186N24.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.59
gene perturbation	0.58
protein domain	0.58
microRNA	0.55
tissue	0.52

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Glutathione Peroxidase 6

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Glutathione Peroxidase 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0