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Tbio
GNG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335281
  • ENSP00000334448
  • ENSG00000186469
  • ENST00000554736
  • ENSP00000452014
  • ENST00000555472
  • ENSP00000451102
  • ENST00000556752
  • ENSP00000451576
  • ENST00000556766
  • ENSP00000451231
  • ENST00000615906
  • ENSP00000484021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
protein complex
0.91
transcription factor perturbation
0.91
virus perturbation
0.72
PubMedID
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.65   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.65   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (650)
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.999999216
p_ni:  7.84e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.999998559
p_ni:  0.000001441
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MOSPD2
Tbio
Novelty:  0.14602473
p_int:  0.999993042
p_ni:  0.000006958
p_wrong:  1e-9
Data Source:  BioPlex
GNB5
Tbio
Novelty:  0.0067714
p_int:  0.999991378
p_ni:  0.000008622
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
KCTD16
Tbio
Novelty:  0.09898256
p_int:  0.99997875
p_ni:  0.000007733
p_wrong:  0.000013517
Data Source:  BioPlex
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.999966856
p_ni:  0.000033144
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
KCTD2
Tdark
Novelty:  0.42992811
p_int:  0.999863403
p_ni:  0.000136533
p_wrong:  6.4e-8
Data Source:  BioPlex
GNB3
Tbio
Novelty:  0.0037117
p_int:  0.99982248
p_ni:  3.48e-7
p_wrong:  0.000177172
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
p_int:  0.999801696
p_ni:  0.000198304
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
P84996
Tbio
Novelty:  0.00284739
p_int:  0.999761775
p_ni:  0.000238226
Score:  0.993
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (120)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
6
8
84.4
waist-hip ratio
1
6
6
74.1
waist circumference
1
3
3
56.6
age-related hearing impairment
1
1
0
6.5
46.1
body mass index
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
84.4
waist-hip ratio
6
74.1
waist circumference
3
56.6
age-related hearing impairment
0
6.5
46.1
body mass index
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 2
710000
Mouse
MGI:102705
14702
Dog
G protein subunit gamma 2
VGNC:53494
610817
Horse
G protein subunit gamma 2
VGNC:18431
100630067
Cow
G protein subunit gamma 2
VGNC:29465
281203
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 2
Mouse
Dog
G protein subunit gamma 2
Horse
G protein subunit gamma 2
Cow
G protein subunit gamma 2
Publication Statistics
PubMed Score 22.65
PubMed score by year
PubTator Score 7.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title