GNG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
- ENST00000335281
- ENSP00000334448
- ENSG00000186469
- ENST00000554736
- ENSP00000452014
- ENST00000555472
- ENSP00000451102
- ENST00000556752
- ENSP00000451576
- ENST00000556766
- ENSP00000451231
- ENST00000615906
- ENSP00000484021
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.92 | ||
protein complex | 0.91 | ||
transcription factor perturbation | 0.91 | ||
virus perturbation | 0.72 | ||
PubMedID | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.06 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 119 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.06 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 119 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0