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Tbio
GNG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335281
  • ENSP00000334448
  • ENSG00000186469
  • ENST00000554736
  • ENSP00000452014
  • ENST00000555472
  • ENSP00000451102
  • ENST00000556752
  • ENSP00000451576
  • ENST00000556766
  • ENSP00000451231
  • ENST00000615906
  • ENSP00000484021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
protein complex
0.91
transcription factor perturbation
0.91
virus perturbation
0.72
PubMedID
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (120)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (650)
1 – 10 of 650
GNB4
Tbio
Novelty: 0.1530232
p_int: 0.999999216
p_ni: 7.84e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.999998559
p_ni: 0.000001441
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MOSPD2
Tbio
Novelty: 0.27833002
p_int: 0.999993042
p_ni: 0.000006958
p_wrong: 1e-9
Data Source: BioPlex
GNB5
Tbio
Novelty: 0.01077999
p_int: 0.999991378
p_ni: 0.000008622
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
KCTD16
Tdark
Novelty: 0.1415969
p_int: 0.99997875
p_ni: 0.000007733
p_wrong: 0.000013517
Data Source: BioPlex
GNAQ
Tbio
Novelty: 0.00176666
p_int: 0.999966856
p_ni: 0.000033144
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
KCTD2
Tdark
Novelty: 0.48979592
p_int: 0.999863403
p_ni: 0.000136533
p_wrong: 6.4e-8
Data Source: BioPlex
GNB3
Tbio
Novelty: 0.0043523
p_int: 0.99982248
p_ni: 3.48e-7
p_wrong: 0.000177172
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.04716243
p_int: 0.999801696
p_ni: 0.000198304
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00259764
p_int: 0.999761775
p_ni: 0.000238226
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.01

PubMed score by year
PubTator Score  7.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer