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Tbio
DEFA3
Neutrophil defensin 3

Protein Summary
Description
Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327857
  • ENSP00000328359
  • ENSG00000239839

Symbol
  • DEF3
  • HP3
  • DEF3
  • HNP3
  • HP-3
  • HNP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.62
protein domain
0.58
cell line
0.51
PubMedID
0.51
tissue
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
7
8
98.7
basophil count
3
9
11
98.4
basophil percentage of leukocytes
2
8
8
97.9
4
3
0
1.3
89.8
granulocyte percentage of myeloid white cells
1
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
8
98.7
basophil count
11
98.4
basophil percentage of leukocytes
8
97.9
0
1.3
89.8
granulocyte percentage of myeloid white cells
2
79.2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P59666-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.977
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.966
Data Source:  STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
Score:  0.961
Data Source:  STRINGDB
DEFB108B
Tdark
Novelty:  0.4704814
Score:  0.943
Data Source:  STRINGDB
DEFB116
Tdark
Novelty:  2.72622256
Score:  0.94
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.933
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.932
Data Source:  STRINGDB
DEFB112
Tdark
Novelty:  0.29597011
Score:  0.93
Data Source:  STRINGDB
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.93
Data Source:  STRINGDB
DEFB124
Tbio
Novelty:  1.65330827
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.42

PubMed score by year
PubTator Score  99.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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