Tbio DEFA1 Neutrophil defensin 1

Protein Summary

Description

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P59665
• P11479
• Q14125
• Q6EZF6

Gene Name

• DEFA1

Ensembl ID

• ENST00000382679
• ENSP00000372126
• ENSG00000206047
• ENST00000382689
• ENSP00000372136
• ENSG00000240247
• ENST00000382692
• ENSP00000372139
• ENST00000644528
• ENSP00000496578
• ENSG00000284983
• ENST00000644617
• ENSP00000496340
• ENSG00000285176
• ENST00000644834
• ENSP00000496058
• ENST00000645146
• ENSP00000493747

Symbol

• DEF1
• DEFA2
• MRS
• HP1
• MRS
• DEF1
• HP-1
• DEFA2
• HNP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.78
disease	0.56
cell line	0.46
tissue	0.37
biological term	0.35

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.19   (req: < 5)

Gene RIFs: 99   (req: <= 3)

Antibodies: 376   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.19   (req: >= 5)

Gene RIFs: 99   (req: > 3)

Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0