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Tbio
DEFA1
Neutrophil defensin 1

Protein Summary
Description
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382679
  • ENSP00000372126
  • ENSG00000206047
  • ENST00000382689
  • ENSP00000372136
  • ENSG00000240247
  • ENST00000382692
  • ENSP00000372139
  • ENST00000644528
  • ENSP00000496578
  • ENSG00000284983
  • ENST00000644617
  • ENSP00000496340
  • ENSG00000285176
  • ENST00000644834
  • ENSP00000496058
  • ENST00000645146
  • ENSP00000493747

Symbol
  • DEF1
  • DEFA2
  • MRS
  • HP1
  • MRS
  • DEF1
  • HP-1
  • DEFA2
  • HNP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
disease
0.56
cell line
0.46
tissue
0.37
biological term
0.35


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.28   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.28   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
5.7
basophil percentage of leukocytes
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
5.7
basophil percentage of leukocytes
1
5
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (112)
1 – 10 of 112
IGFBP2
Tchem
Novelty: 0.00083618
p_int: 0.999992871
p_ni: 2.6e-7
p_wrong: 0.000006869
Score: 0.188
Data Source: BioPlex,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.999982868
p_ni: 0.000017132
Data Source: BioPlex
TKFC
Tbio
Family: Enzyme
Novelty: 0.00380602
p_int: 0.999952083
p_ni: 0.000047885
p_wrong: 3.2e-8
Data Source: BioPlex
CTBS
Tbio
Family: Enzyme
Novelty: 0.00956005
p_int: 0.999940077
p_ni: 0.000056363
p_wrong: 0.00000356
Score: 0.2
Data Source: BioPlex,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.999918494
p_ni: 0.000081494
p_wrong: 1.2e-8
Data Source: BioPlex
LIFR
Tbio
Novelty: 0.00514085
p_int: 0.999907335
p_ni: 0.000069454
p_wrong: 0.00002321
Data Source: BioPlex
SUSD1
Tdark
Novelty: 0.54249826
p_int: 0.999829033
p_ni: 0.000170955
p_wrong: 1.2e-8
Data Source: BioPlex
CTSF
Tchem
Family: Enzyme
Novelty: 0.01359417
p_int: 0.999807512
p_ni: 0.000192484
p_wrong: 4e-9
Data Source: BioPlex
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 0.999505609
p_ni: 0.000494391
Data Source: BioPlex
ARSB
Tbio
Family: Enzyme
Novelty: 0.01044355
p_int: 0.999433313
p_ni: 0.000566407
p_wrong: 2.8e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  180.28

PubMed score by year
PubTator Score  111.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer