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Tchem
TAS2R40
Taste receptor type 2 member 40

Protein Summary
Description
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408947
  • ENSP00000386210
  • ENSG00000221937

Symbol
  • GPR60
  • GPR60
  • T2R40
  • T2R58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
metabolite
0.45
cell line
0.4
tissue
0.37
pathway
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.95
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.949
Data Source:  STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.945
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.942
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.942
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.936
Data Source:  STRINGDB
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.934
Data Source:  STRINGDB
TAS2R31
Tchem
Family:  GPCR
Novelty:  0.08517774
Score:  0.921
Data Source:  STRINGDB
S1PR4
Tclin
Family:  GPCR
Novelty:  0.01523676
Score:  0.921
Data Source:  STRINGDB
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
3
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
83
IDG Resources
Items per page:
10
1 – 10 of 20
Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
image for pcDNA5/FRT/TO-GAlpha13-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
image for pcDNA5/FRT/TO-GAlpha15-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha11-RLuc8
image for pcDNA5/FRT/TO-GAlpha11-RLuc8
Details:
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Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 40
VGNC:8774
472611
Macaque
taste 2 receptor member 40
706077
Mouse
MGI:2681312
387515
Rat
RGD:1562314
500101
Dog
taste 2 receptor member 40
VGNC:47119
608842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 40
Macaque
taste 2 receptor member 40
Mouse
Rat
Dog
taste 2 receptor member 40
Publication Statistics
PubMed Score 2.04
PubMed score by year
PubTator Score 1.08
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title