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Tchem
TAS2R38
Taste receptor type 2 member 38

Protein Summary
Description
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547270
  • ENSP00000448219
  • ENSG00000257138

Symbol
  • PTC
  • PTC
  • T2R38
  • T2R61
  • THIOT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.63
biological term
0.61
tissue sample
0.57
cell line
0.55
phenotype
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.46   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.46   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
isoprenaline
Rendered image for isoprenaline
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
2
2
3
95.8
bitter alcoholic beverage consumption measurement
1
1
1
42.3
tea consumption measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
3
95.8
bitter alcoholic beverage consumption measurement
1
42.3
tea consumption measurement
1
40.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 38
VGNC:8771
493889
Macaque
taste 2 receptor member 38
695549
Mouse
MGI:2681306
387513
Dog
taste 2 receptor member 38
VGNC:47117
100271737
Horse
taste 2 receptor member 38
VGNC:23881
106783090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 38
Macaque
taste 2 receptor member 38
Mouse
Dog
taste 2 receptor member 38
Horse
taste 2 receptor member 38
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P59533-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (261)
1 – 10 of 261
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.976900171
p_ni:  0.022303416
p_wrong:  0.000796413
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.764779449
p_ni:  0.235217964
p_wrong:  0.000002588
Data Source:  BioPlex
TAS2R16
Tchem
Family:  GPCR
Novelty:  0.03181719
Score:  0.985
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.971
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.97
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.966
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.965
Data Source:  STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.961
Data Source:  STRINGDB
SSTR3
Tclin
Family:  GPCR
Novelty:  0.00899073
Score:  0.954
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.951
Data Source:  STRINGDB
Publication Statistics
PubMed Score  246.46

PubMed score by year
PubTator Score  157.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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