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Tbio
DAOA
D-amino acid oxidase activator

Protein Summary
Description
Seems to activate D-amino acid oxidase. This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329625
  • ENSP00000329951
  • ENSG00000182346
  • ENST00000375936
  • ENSP00000365103
  • ENST00000473269
  • ENSP00000470244
  • ENST00000559369
  • ENSP00000453831
  • ENST00000600388
  • ENSP00000472260
  • ENST00000618629
  • ENSP00000483757

Symbol
  • G72
  • LG72
  • SG72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.74
disease
0.46
phenotype
0.46
cell line
0.44
cellular component
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.69   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.69   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (26)
1 – 10 of 26
DAO
Tchem
Family: Enzyme
Novelty: 0.00414923
Score: 0.918
Data Source: STRINGDB
DTNBP1
Tbio
Novelty: 0.00341619
Score: 0.787
Data Source: STRINGDB
DISC1
Tbio
Novelty: 0.00183442
Score: 0.731
Data Source: STRINGDB
NRG1
Tbio
Novelty: 0.00095246
Score: 0.7
Data Source: STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.669
Data Source: STRINGDB
RGS4
Tchem
Novelty: 0.00342656
Score: 0.653
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00340947
Score: 0.553
Data Source: STRINGDB
TAAR6
Tbio
Family: GPCR
Novelty: 0.00594707
Score: 0.53
Data Source: STRINGDB
ZNF804A
Tbio
Novelty: 0.00751648
Score: 0.527
Data Source: STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
Score: 0.525
Data Source: STRINGDB
Publication Statistics
PubMed Score  100.69

PubMed score by year
PubTator Score  62.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer