NLRP12
NACHT, LRR and PYD domains-containing protein 12
Protein Summary
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
- ENST00000324134
- ENSP00000319377
- ENSG00000142405
- ENST00000391773
- ENSP00000375653
- ENST00000391775
- ENSP00000375655
- NALP12
- PYPAF7
- RNO
- RNO
- PAN6
- RNO2
- FCAS2
- NALP12
- PYPAF7
- CLR19.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
molecular function | 0.93 | ||
protein domain | 0.85 | ||
tissue sample | 0.67 | ||
transcription factor | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.36 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 301 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.36 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 301 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0