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Tbio
NLRP11
NACHT, LRR and PYD domains-containing protein 11

Protein Summary
Description
Involved in inflammation. This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000589093
  • ENSP00000466285
  • ENSG00000179873
  • ENST00000589824
  • ENSP00000468082
  • ENST00000592953
  • ENSP00000468196

Symbol
  • NALP11
  • NOD17
  • PAN10
  • PYPAF6
  • NOD17
  • PAN10
  • NALP11
  • PYPAF6
  • PYPAF7
  • CLR19.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cellular component
0.9
phenotype
0.63
trait
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (22)
1 – 10 of 22
ADGRL1
Tbio
Family: GPCR
Novelty: 0.01343585
Score: 0.683
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.01111728
Score: 0.683
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00182297
Score: 0.683
Data Source: STRINGDB
OR6K2
Tdark
Family: oGPCR
Score: 0.557
Data Source: STRINGDB
ZNF563
Tdark
Family: TF
Novelty: 17
Score: 0.545
Data Source: STRINGDB
MEFV
Tbio
Novelty: 0.00090769
Score: 0.543
Data Source: STRINGDB
OR2T6
Tdark
Family: oGPCR
Score: 0.515
Data Source: STRINGDB
OR9G4
Tdark
Family: oGPCR
Score: 0.491
Data Source: STRINGDB
OR52M1
Tdark
Family: oGPCR
Score: 0.473
Data Source: STRINGDB
OR4K15
Tdark
Family: oGPCR
Novelty: 4
Score: 0.473
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.47

PubMed score by year
PubTator Score  6.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer