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Tbio
HIST1H2BD
Histone H2B type 1-D

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289316
  • ENSP00000289316
  • ENSG00000158373
  • ENST00000377777
  • ENSP00000367008

Symbol
  • H2BFB
  • HIRIP2
  • H2B/a
  • H2B/b
  • H2B/g
  • H2B/h
  • H2B/k
  • H2B/l
  • H2BFA
  • H2BFB
  • H2BFG
  • H2BFH
  • H2BFK
  • H2BFL
  • H2B.1B
  • HIRIP2
  • HIST1H2BC
  • HIST1H2BE
  • HIST1H2BF
  • HIST1H2BG
  • HIST1H2BI
  • dJ221C16.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
gene perturbation
0.94
PubMedID
0.88
cellular component
0.83
histone modification site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
95.8
C-reactive protein measurement
1
1
1
93.6
mathematical ability
2
1
2
88.1
body height
1
1
1
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
95.8
C-reactive protein measurement
1
93.6
mathematical ability
2
88.1
body height
1
76.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3710645
665622
Rat
RGD:1307126
361247
Horse
histone H2B type 1-M
100053645
Cow
histone cluster 1, H2bd
519935
Pig
histone cluster 1, H2bd
100157327
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
histone H2B type 1-M
Cow
histone cluster 1, H2bd
Pig
histone cluster 1, H2bd
Pathways (92)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 89
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (417)
1 – 10 of 417
H2AFX
Tbio
Novelty: 0.00048694
p_int: 1
Score: 0.97
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999999877
p_ni: 1.23e-7
Score: 0.71
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999999799
p_ni: 1.5e-8
p_wrong: 1.87e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.999999636
p_ni: 3.64e-7
Score: 0.627
Data Source: BioPlex,STRINGDB
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.999973984
p_ni: 0.000026013
p_wrong: 4e-9
Score: 0.349
Data Source: BioPlex,STRINGDB
HIST1H2AC
Tdark
Novelty: 0.4785744
Score: 0.995
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.982
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.973
Data Source: STRINGDB
HIST2H2AA3
Tbio
Novelty: 0.00065445
Score: 0.972
Data Source: STRINGDB
MSH4
Tbio
Novelty: 0.00838156
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.06

PubMed score by year
PubTator Score  3.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer