Tbio TIRAP Toll/interleukin-1 receptor domain-containing adapter protein

Protein Summary

Description

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P58753
• B3KW65
• Q56UH9
• Q56UI0
• Q8N5E5
• TIR domain-containing adapter protein

Gene Name

• TIRAP

Ensembl ID

• ENST00000392678
• ENSP00000376445
• ENSG00000150455
• ENST00000392679
• ENSP00000376446
• ENST00000392680
• ENSP00000376447
• ENST00000479770
• ENSP00000436967

Symbol

• MAL
• Mal
• wyatt
• BACTS1
• MyD88-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
histone modification site profile	0.88
molecular function	0.84
virus perturbation	0.79
tissue sample	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.81   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 487   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.81   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0