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Tbio
SLC26A5
Prestin

Protein Summary
Description
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transpor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306312
  • ENSP00000304783
  • ENSG00000170615
  • ENST00000339444
  • ENSP00000342396
  • ENST00000356767
  • ENSP00000349210
  • ENST00000393723
  • ENSP00000377324
  • ENST00000393730
  • ENSP00000377331
  • ENST00000393735
  • ENSP00000377336
  • ENST00000432958
  • ENSP00000389733

Symbol
  • PRES
  • PRES
  • DFNB61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.71
cell type or tissue
0.68
histone modification site profile
0.66
molecular function
0.6


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.77   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.77   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
67.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 5
VGNC:8760
742668
Macaque
solute carrier family 26 member 5
696074
Mouse
MGI:1933154
80979
Rat
RGD:69334
83819
Dog
solute carrier family 26 member 5
VGNC:46325
483274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 5
Macaque
solute carrier family 26 member 5
Mouse
Rat
Dog
solute carrier family 26 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P58743-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (54)
1 – 10 of 54
HBE1
Tbio
Novelty: 0.00125958
Score: 0.723
Data Source: STRINGDB
OCM2
Tdark
Novelty: 0.08257025
Score: 0.664
Data Source: STRINGDB
OCM
Tbio
Novelty: 0.00702069
Score: 0.661
Data Source: STRINGDB
PITPNM1
Tbio
Novelty: 0.0063062
Score: 0.661
Data Source: STRINGDB
PTPRQ
Tbio
Family: Enzyme
Novelty: 0.06874197
Score: 0.653
Data Source: STRINGDB
PTPRR
Tbio
Family: Enzyme
Novelty: 0.02065754
Score: 0.646
Data Source: STRINGDB
CPD
Tbio
Family: Enzyme
Novelty: 0.02105758
Score: 0.635
Data Source: STRINGDB
GPC5
Tbio
Novelty: 0.01257358
Score: 0.631
Data Source: STRINGDB
SPART
Tbio
Novelty: 0.01524727
Score: 0.624
Data Source: STRINGDB
FOXP2
Tbio
Family: TF
Novelty: 0.00190504
Score: 0.599
Data Source: STRINGDB
Publication Statistics
PubMed Score  739.77

PubMed score by year
PubTator Score  188.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer