Tbio YBEY Endoribonuclease YbeY

Protein Summary

Description

Single strand-specific metallo-endoribonuclease involved in rRNA maturation. This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P58557
• B7WPA9
• B7WPF7
• D3DSN2

Gene Name

• YBEY

Ensembl ID

• ENST00000329319
• ENSP00000329614
• ENSG00000182362
• ENST00000339195
• ENSP00000340675
• ENST00000397691
• ENSP00000380805
• ENST00000397692
• ENSP00000380806
• ENST00000397694
• ENSP00000380808
• ENST00000397701
• ENSP00000380813

Symbol

• C21orf57
• C21orf57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.74
histone modification site profile	0.64
microRNA	0.63
transcription factor binding site profile	0.63
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.24   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 33   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.24   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0