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Tbio
MTPN
Myotrophin

Protein Summary
Description
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce le ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393085
  • ENSP00000376800
  • ENSG00000105887

Symbol
  • V-1
  • GCDP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.99
cell type or tissue
0.84
microRNA
0.8
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
16.4
platelet count
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
16.4
platelet count
1
3.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotrophin
VGNC:4437
463756
Macaque
myotrophin
708941
Mouse
MGI:99445
14489
Rat
RGD:619806
79215
Dog
myotrophin
VGNC:51815
403487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotrophin
Macaque
myotrophin
Mouse
Rat
Dog
myotrophin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P58546-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (65)
1 – 10 of 65
CAPZB
Tbio
Novelty: 0.03509224
Score: 0.94
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.912
Data Source: STRINGDB
NPLOC4
Tbio
Novelty: 0.01690434
Score: 0.869
Data Source: STRINGDB
NUP93
Tbio
Novelty: 0.0248311
Score: 0.857
Data Source: STRINGDB
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
Score: 0.825
Data Source: STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
Score: 0.822
Data Source: STRINGDB
GRK6
Tchem
Family: Kinase
Novelty: 0.02740874
Score: 0.822
Data Source: STRINGDB
ENOPH1
Tbio
Family: Enzyme
Novelty: 0.07679925
Score: 0.818
Data Source: STRINGDB
EEF1B2
Tbio
Novelty: 0.00970356
Score: 0.818
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00419724
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.17

PubMed score by year
PubTator Score  31.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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