Tbio CLRN1 Clarin-1

Protein Summary

Description

May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P58418
• D3DNJ3
• E1ACU9
• Q8N6A9

Gene Name

• CLRN1

Ensembl ID

• ENST00000295911
• ENSP00000295911
• ENSG00000163646
• ENST00000327047
• ENSP00000322280
• ENST00000328863
• ENSP00000329158

Symbol

• USH3A
• RP61
• USH3
• USH3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.64
kinase perturbation	0.6
transcription factor	0.57
disease	0.48
cell type or tissue	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.66   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.66   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0