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Tbio
CLRN1
Clarin-1

Protein Summary
Description
May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295911
  • ENSP00000295911
  • ENSG00000163646
  • ENST00000327047
  • ENSP00000322280
  • ENST00000328863
  • ENSP00000329158

Symbol
  • USH3A
  • RP61
  • USH3
  • USH3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.64
kinase perturbation
0.6
transcription factor
0.57
disease
0.48
cell type or tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.89   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (66)
1 – 10 of 66
USH1C
Tbio
Novelty: 0.01066917
Score: 0.914
Data Source: STRINGDB
USH1G
Tbio
Novelty: 0.02912203
Score: 0.852
Data Source: STRINGDB
USH2A
Tbio
Novelty: 0.00223387
Score: 0.842
Data Source: STRINGDB
WHRN
Tbio
Novelty: 0.01886351
Score: 0.835
Data Source: STRINGDB
PDZD7
Tbio
Novelty: 0.09467006
Score: 0.834
Data Source: STRINGDB
CIB2
Tbio
Novelty: 0.03578691
Score: 0.822
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.82
Data Source: STRINGDB
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
Score: 0.816
Data Source: STRINGDB
CDH23
Tbio
Novelty: 0.00588227
Score: 0.803
Data Source: STRINGDB
MYO7A
Tbio
Novelty: 0.00314435
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.89

PubMed score by year
PubTator Score  45.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer