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Tbio
P58401
Neurexin-2-beta

Protein Summary
Description
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301894
  • ENSP00000301894
  • ENSG00000110076
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.82
transcription factor
0.78
tissue sample
0.69
PubMedID
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (174)
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
Score:  0.998
Data Source:  STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
Score:  0.998
Data Source:  STRINGDB
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
Score:  0.998
Data Source:  STRINGDB
NLGN4X
Tbio
Family:  Enzyme
Novelty:  0.01004489
Score:  0.997
Data Source:  STRINGDB
LRRTM1
Tbio
Novelty:  0.0409182
Score:  0.984
Data Source:  STRINGDB
LRRTM2
Tbio
Novelty:  0.08084156
Score:  0.983
Data Source:  STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.979
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.977
Data Source:  STRINGDB
LRRTM3
Tbio
Novelty:  0.18633527
Score:  0.972
Data Source:  STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
32
70
6.8
99.9
urate measurement
9
32
70
6.8
99.9
uric acid measurement
8
9
24
10.5
99.8
uric acid measurement
8
9
24
10.5
99.8
4
3
0
1.4
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
70
6.8
99.9
urate measurement
70
6.8
99.9
uric acid measurement
24
10.5
99.8
uric acid measurement
24
10.5
99.8
0
1.4
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurexin 2
VGNC:3086
451297
Macaque
neurexin 2
574175
Mouse
MGI:1096362
18190
Rat
RGD:620211
116595
Dog
neurexin 2
VGNC:43979
483760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurexin 2
Macaque
neurexin 2
Mouse
Rat
Dog
neurexin 2
Publication Statistics
PubMed Score 101.10
PubMed score by year
PubTator Score 13.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title