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Tbio
NRXN1
Neurexin-1-beta

Protein Summary
Description
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342183
  • ENSP00000341184
  • ENSG00000179915
  • ENST00000401710
  • ENSP00000385580

Symbol
  • PTHSL2
  • SCZD17
  • Hs.22998
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.92
biological process
0.87
kinase perturbation
0.81
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.31   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.31   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Non-integrin membrane-ECM interactions
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Neurexins and neuroligins
Neuronal System
Non-integrin membrane-ECM interactions
Protein-protein interactions at synapses
Gene Ontology Terms (62)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (277)
1 – 10 of 277
NLGN3
Tbio
Family: Enzyme
Novelty: 0.01096841
Score: 0.998
Data Source: STRINGDB
NLGN1
Tbio
Family: Enzyme
Novelty: 0.01074328
Score: 0.998
Data Source: STRINGDB
NLGN4X
Tbio
Family: Enzyme
Novelty: 0.01405852
Score: 0.997
Data Source: STRINGDB
NLGN2
Tbio
Family: Enzyme
Novelty: 0.01593176
Score: 0.997
Data Source: STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.0064209
Score: 0.987
Data Source: STRINGDB
LRRTM2
Tbio
Novelty: 0.19711103
Score: 0.985
Data Source: STRINGDB
LRRTM1
Tbio
Novelty: 0.05800638
Score: 0.983
Data Source: STRINGDB
LRRTM3
Tbio
Novelty: 0.23649758
Score: 0.975
Data Source: STRINGDB
SHANK2
Tbio
Novelty: 0.00056413
Score: 0.975
Data Source: STRINGDB
SYT1
Tbio
Novelty: 0.00202951
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  188.31

PubMed score by year
PubTator Score  113.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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