You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
P58400
Neurexin-1-beta

Protein Summary
Description
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342183
  • ENSP00000341184
  • ENSG00000179915
  • ENST00000401710
  • ENSP00000385580

Symbol
  • PTHSL2
  • SCZD17
  • Hs.22998
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.92
biological process
0.87
kinase perturbation
0.81
disease
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.81   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.81   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (277)
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
Score:  0.998
Data Source:  STRINGDB
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
Score:  0.998
Data Source:  STRINGDB
NLGN4X
Tbio
Family:  Enzyme
Novelty:  0.01004489
Score:  0.997
Data Source:  STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
Score:  0.997
Data Source:  STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.987
Data Source:  STRINGDB
LRRTM2
Tbio
Novelty:  0.08084156
Score:  0.985
Data Source:  STRINGDB
LRRTM1
Tbio
Novelty:  0.0409182
Score:  0.983
Data Source:  STRINGDB
LRRTM3
Tbio
Novelty:  0.18633527
Score:  0.975
Data Source:  STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.975
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Non-integrin membrane-ECM interactions
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Neurexins and neuroligins
Neuronal System
Non-integrin membrane-ECM interactions
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (62)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
7
8
1.1
87.9
chronotype measurement
3
7
8
1.1
87.9
body mass index
3
3
6
87.5
body mass index
3
3
6
87.5
self reported educational attainment
4
9
18
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
8
1.1
87.9
chronotype measurement
8
1.1
87.9
body mass index
6
87.5
body mass index
6
87.5
self reported educational attainment
18
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1096391
18189
Horse
neurexin 1
VGNC:20895
100052908
Chicken
neurexin 1
CGNC:49297
395398
Zebrafish
ZDB-GENE-070206-1
565531
C. elegans
179503
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
neurexin 1
Chicken
neurexin 1
Zebrafish
C. elegans
Publication Statistics
PubMed Score 339.81
PubMed score by year
PubTator Score 113.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title