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Tbio
ADAMTS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

Protein Classes
Protein Summary
Description
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352040
  • ENSP00000344847
  • ENSG00000151388
  • ENST00000504830
  • ENSP00000422554

Symbol
  • PRO4389
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
trait
0.75
cell line
0.7
biological process
0.67
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
4
5
2
3.3
99.3
suntan
2
2
2
95.7
3
2
1
1.6
92
skin pigmentation measurement
3
3
4
90.8
2
2
0
1.8
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3.3
99.3
suntan
2
95.7
1
1.6
92
skin pigmentation measurement
4
90.8
0
1.8
89.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 12
VGNC:3890
461952
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 12
701750
Mouse
MGI:2146046
239337
Rat
RGD:1307323
294809
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 12
VGNC:50867
479369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 12
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 12
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P58397-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (61)
1 – 10 of 61
SNRK
Tchem
Family:  Kinase
Novelty:  0.00707197
p_int:  0.999999983
p_ni:  1.5e-8
p_wrong:  2e-9
Score:  0.651
Data Source:  BioPlex,STRINGDB
USF1
Tbio
Family:  TF
Novelty:  0.00136587
p_int:  0.999956746
p_ni:  0.000043244
p_wrong:  9e-9
Score:  0.808
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.997943597
p_ni:  0.002056403
Data Source:  BioPlex
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.99415696
p_ni:  0.00584304
Score:  0.193
Data Source:  BioPlex,STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.991848163
p_ni:  0.008151837
Score:  0.541
Data Source:  BioPlex,STRINGDB
USF2
Tbio
Family:  TF
Novelty:  0.00516415
p_int:  0.93258839
p_ni:  0.000138513
p_wrong:  0.067273097
Score:  0.823
Data Source:  BioPlex,STRINGDB
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.879645309
p_ni:  0.120354691
Score:  0.187
Data Source:  BioPlex,STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.933
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.929
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.71

PubMed score by year
PubTator Score  21.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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