Tbio MLF1 Myeloid leukemia factor 1

Protein Summary

Description

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P58340
• E9PEU9
• Q2TLE3
• Q2TLE5
• Q8N8F8
• Q96MH1

Gene Name

• MLF1

Ensembl ID

• ENST00000355893
• ENSP00000348157
• ENSG00000178053
• ENST00000359117
• ENSP00000352025
• ENST00000392822
• ENSP00000376568
• ENST00000469452
• ENSP00000418595
• ENST00000471745
• ENSP00000420134
• ENST00000478894
• ENSP00000417777
• ENST00000482628
• ENSP00000417141
• ENST00000484955
• ENSP00000417835
• ENST00000618075
• ENSP00000484169
• ENST00000619577
• ENSP00000483337

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
transcription factor perturbation	0.8
disease perturbation	0.79
gene perturbation	0.68
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Myeloid Leukemia Factor 1

DTO Classes

Protein / Signaling / Myeloid Leukemia Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 472   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0