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Tbio
ANTXR2
Anthrax toxin receptor 2

Protein Classes
Protein Summary
Description
Necessary for cellular interactions with laminin and the extracellular matrix. This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307333
  • ENSP00000306185
  • ENSG00000163297
  • ENST00000346652
  • ENSP00000314883
  • ENST00000403729
  • ENSP00000385575

Symbol
  • CMG2
  • HFS
  • ISH
  • JHF
  • CMG2
  • CMG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
small molecule perturbation
0.82
cellular component
0.77
gene perturbation
0.74
transcription factor binding site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.19   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.19   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
91.5
lymphocyte percentage of leukocytes
2
2
2
66.6
myeloid white cell count
1
1
1
60.4
neutrophil percentage of leukocytes
2
2
2
58.8
monocyte count
1
1
1
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
91.5
lymphocyte percentage of leukocytes
2
66.6
myeloid white cell count
1
60.4
neutrophil percentage of leukocytes
2
58.8
monocyte count
1
55.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anthrax toxin receptor 2
VGNC:560
471191
Macaque
anthrax toxin receptor 2
696513
Mouse
MGI:1919164
71914
Rat
RGD:1561294
305633
Dog
ANTXR cell adhesion molecule 2
VGNC:37936
487821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anthrax toxin receptor 2
Macaque
anthrax toxin receptor 2
Mouse
Rat
Dog
ANTXR cell adhesion molecule 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Uptake and actions of bacterial toxins
Reactome
Uptake and function of anthrax toxins
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Uptake and actions of bacterial toxins
Uptake and function of anthrax toxins
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
ELOA
Tbio
Novelty: 0.04334224
p_int: 0.964109201
p_ni: 0.005390922
p_wrong: 0.030499877
Score: 0.379
Data Source: BioPlex,STRINGDB
HS1BP3
Tbio
Novelty: 0.08876712
p_int: 0.937558498
p_ni: 0.062441411
p_wrong: 9.1e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.900009557
p_ni: 0.099990439
p_wrong: 4e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.898262247
p_ni: 0.101688665
p_wrong: 0.000049088
Score: 0.187
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.969
Data Source: Reactome,STRINGDB
ANTXR1
Tbio
Novelty: 0.00508081
Score: 0.906
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.774
Data Source: STRINGDB
SCUBE1
Tbio
Novelty: 0.03241851
Score: 0.665
Data Source: STRINGDB
BICD1
Tbio
Novelty: 0.02109123
Score: 0.621
Data Source: STRINGDB
DCBLD2
Tbio
Novelty: 0.06514947
Score: 0.607
Data Source: STRINGDB
Publication Statistics
PubMed Score  194.19

PubMed score by year
PubTator Score  69.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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