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Tchem
ANTXR2
Anthrax toxin receptor 2

Protein Summary
Description
Necessary for cellular interactions with laminin and the extracellular matrix. This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307333
  • ENSP00000306185
  • ENSG00000163297
  • ENST00000346652
  • ENSP00000314883
  • ENST00000403729
  • ENSP00000385575

Symbol
  • CMG2
  • HFS
  • ISH
  • JHF
  • CMG2
  • CMG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
small molecule perturbation
0.82
cellular component
0.77
gene perturbation
0.74
transcription factor binding site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.02   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.02   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0