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Tbio
VSX2
Visual system homeobox 2

Protein Summary
Description
Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity). This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261980
  • ENSP00000261980
  • ENSG00000119614

Symbol
  • CHX10
  • HOX10
  • RET1
  • CHX10
  • HOX10
  • MCOP2
  • MCOPCB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
biological process
0.64
hub protein
0.63
PubMedID
0.56
microRNA
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.41   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.41   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
visual system homeobox 2
VGNC:3289
741059
Macaque
visual system homeobox 2
699261
Mouse
MGI:88401
12677
Rat
RGD:621215
171360
Dog
visual system homeobox 2
VGNC:48313
490780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
visual system homeobox 2
Macaque
visual system homeobox 2
Mouse
Rat
Dog
visual system homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P58304-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (96)
1 – 10 of 96
USP20
Tbio
Family: Enzyme
Novelty: 0.06647037
p_int: 0.999984917
p_ni: 0.000015083
Score: 0.21
Data Source: BioPlex,STRINGDB
USP12
Tbio
Family: Enzyme
Novelty: 0.0460009
p_int: 0.999815381
p_ni: 0.000184608
p_wrong: 1.2e-8
Score: 0.527
Data Source: BioPlex,STRINGDB
WDR20
Tbio
Novelty: 0.03031804
p_int: 0.999805535
p_ni: 0.000194464
p_wrong: 1e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
p_int: 0.989025521
p_ni: 0.010974211
p_wrong: 2.68e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
USP33
Tbio
Family: Enzyme
Novelty: 0.04411285
p_int: 0.969562731
p_ni: 0.030436653
p_wrong: 6.16e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.910277058
p_ni: 0.089722942
Score: 0.203
Data Source: BioPlex,STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.898714451
p_ni: 0.101285548
Data Source: BioPlex
ZNF703
Tbio
Novelty: 0.03956045
p_int: 0.874892459
p_ni: 0.125081668
p_wrong: 0.000025873
Score: 0.181
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.837813202
p_ni: 0.162186797
p_wrong: 1e-9
Score: 0.519
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.806529538
p_ni: 0.193470462
Data Source: BioPlex
Publication Statistics
PubMed Score  207.41

PubMed score by year
PubTator Score  65.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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