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Tchem
LOXL3
Lysyl oxidase homolog 3

Protein Summary
Description
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264094
  • ENSP00000264094
  • ENSG00000115318
  • ENST00000393937
  • ENSP00000377512

Symbol
  • LOXL
  • LOXL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.69
small molecule perturbation
0.63
histone modification site profile
0.62
molecular function
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.06   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
disulfiram
Rendered image for disulfiram
thiram
Rendered image for thiram
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
64.9
body height
1
1
1
59.9
platelet crit
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
64.9
body height
1
59.9
platelet crit
1
59
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 3
VGNC:290
459340
Macaque
lysyl oxidase like 3
709834
Mouse
MGI:1337004
16950
Rat
RGD:1311011
312478
Dog
lysyl oxidase like 3
VGNC:42740
483101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 3
Macaque
lysyl oxidase like 3
Mouse
Rat
Dog
lysyl oxidase like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P58215-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (252)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Protein-Protein Interactions (33)
1 – 10 of 33
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.99984134
p_ni:  0.000158625
p_wrong:  3.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.999581165
p_ni:  0.000418831
p_wrong:  4e-9
Data Source:  BioPlex
MSI1
Tbio
Novelty:  0.00670282
p_int:  0.987470628
p_ni:  0.012529372
Score:  0.369
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.978297126
p_ni:  0.021702871
p_wrong:  4e-9
Data Source:  BioPlex
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.863054639
p_ni:  0.136945361
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.837697581
p_ni:  0.162302419
Score:  0.292
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.822345301
p_ni:  0.177654689
p_wrong:  9e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
SENP5
Tbio
Family:  Enzyme
Novelty:  0.0510532
p_int:  0.8145763
p_ni:  0.185423697
p_wrong:  3e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
MSI2
Tbio
Novelty:  0.01716735
p_int:  0.797203251
p_ni:  0.202796749
Score:  0.188
Data Source:  BioPlex,STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
p_int:  0.765499357
p_ni:  0.009109812
p_wrong:  0.225390831
Score:  0.218
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.06

PubMed score by year
PubTator Score  27.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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