You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
INHBE
Inhibin beta E chain

Protein Summary
Description
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266646
  • ENSP00000266646
  • ENSG00000139269
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
protein domain
0.85
cell type or tissue
0.7
small molecule perturbation
0.64
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
7
5
7
5.2
98.6
high density lipoprotein cholesterol measurement
8
7
17
97.3
triglyceride measurement
8
7
14
2.7
96.2
glomerular filtration rate
4
3
4
91.6
apolipoprotein A 1 measurement
2
2
2
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
7
5.2
98.6
high density lipoprotein cholesterol measurement
17
97.3
triglyceride measurement
14
2.7
96.2
glomerular filtration rate
4
91.6
apolipoprotein A 1 measurement
2
84.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibin subunit beta E
VGNC:8423
452013
Macaque
inhibin beta E subunit [Source:HGNC Symbol;Acc:HGNC:24029]
Mouse
MGI:109269
16326
Rat
RGD:621196
83711
Dog
inhibin subunit beta E
VGNC:54315
100856447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibin subunit beta E
Macaque
inhibin beta E subunit [Source:HGNC Symbol;Acc:HGNC:24029]
Mouse
Rat
Dog
inhibin subunit beta E
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P58166-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Glycoprotein hormones (R-HSA-209822)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycoprotein hormones
Reactome
Metabolism of proteins
Reactome
Peptide hormone biosynthesis
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Glycoprotein hormones
Metabolism of proteins
Peptide hormone biosynthesis
Peptide hormone metabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (42)
1 – 10 of 42
COLEC10
Tbio
Novelty:  0.02593638
p_int:  0.999854759
p_ni:  0.000109886
p_wrong:  0.000035354
Score:  0.27
Data Source:  BioPlex,STRINGDB
C1QTNF9B
Tdark
Novelty:  0.7643008
p_int:  0.999748986
p_ni:  0.000247321
p_wrong:  0.000003693
Data Source:  BioPlex
APP
Tchem
Novelty:  0.00008964
p_int:  0.999450535
p_ni:  0.000201982
p_wrong:  0.000347482
Score:  0.274
Data Source:  BioPlex,STRINGDB
UST
Tbio
Family:  Enzyme
Novelty:  0.03897672
p_int:  0.997206711
p_ni:  0.000843163
p_wrong:  0.001950126
Score:  0.183
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.996968963
p_ni:  0.001534674
p_wrong:  0.001496363
Data Source:  BioPlex
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.996232503
p_ni:  0.00154141
p_wrong:  0.002226087
Data Source:  BioPlex
FAM169A
Tdark
Novelty:  0.53420521
p_int:  0.956430752
p_ni:  1.7e-8
p_wrong:  0.043569231
Score:  0.369
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.928301035
p_ni:  0.071698965
Score:  0.182
Data Source:  BioPlex,STRINGDB
MYO1F
Tbio
Novelty:  0.06367196
p_int:  0.923417962
p_ni:  0.07570418
p_wrong:  0.000877858
Score:  0.206
Data Source:  BioPlex,STRINGDB
PRMT7
Tchem
Family:  Epigenetic
Novelty:  0.02310897
p_int:  0.890157488
p_ni:  0.000130802
p_wrong:  0.109711711
Score:  0.187
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.37

PubMed score by year
PubTator Score  536.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: