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Tbio
SPINK7
Serine protease inhibitor Kazal-type 7

Protein Summary
Description
Probable serine protease inhibitor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274565
  • ENSP00000274565
  • ENSG00000145879

Symbol
  • ECG2
  • ECG2
  • ECRG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
biological term
0.42
phenotype
0.42
virus perturbation
0.41
tissue
0.39


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.74   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.74   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 7 (putative)
VGNC:4176
741252
Macaque
serine peptidase inhibitor, Kazal type 7 (putative)
709674
Mouse
MGI:3644691
408198
Rat
RGD:1303077
408237
Dog
serine peptidase inhibitor, Kazal type 7 (putative)
100686763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 7 (putative)
Macaque
serine peptidase inhibitor, Kazal type 7 (putative)
Mouse
Rat
Dog
serine peptidase inhibitor, Kazal type 7 (putative)
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P58062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
LYPD1
Tbio
Novelty: 0.10740408
p_int: 0.999993468
p_ni: 2.1e-8
p_wrong: 0.000006511
Score: 0.175
Data Source: BioPlex,STRINGDB
SMPX
Tbio
Novelty: 0.05084864
p_int: 0.998963519
p_ni: 0.001036141
p_wrong: 3.4e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
p_int: 0.99692196
p_ni: 0.00307804
Data Source: BioPlex
ZER1
Tbio
Novelty: 0.02989698
p_int: 0.979022995
p_ni: 0.020977005
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00661254
p_int: 0.968495012
p_ni: 0.031504988
Data Source: BioPlex
IDE
Tchem
Family: Enzyme
Novelty: 0.00207793
p_int: 0.936826778
p_ni: 0.063173222
Score: 0.183
Data Source: BioPlex,STRINGDB
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.896982765
p_ni: 0.103017235
Data Source: BioPlex
GID8
Tbio
Novelty: 0.21243963
p_int: 0.764691694
p_ni: 0.235308306
Score: 0.169
Data Source: BioPlex,STRINGDB
SPINK6
Tbio
Family: Enzyme
Novelty: 0.11687263
Score: 0.695
Data Source: STRINGDB
HMBOX1
Tbio
Family: TF
Novelty: 0.02455652
Score: 0.694
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.74

PubMed score by year
PubTator Score  49.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer