Protein Classes
Protein Summary
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydr ...more
- ENST00000253063
- ENSP00000253063
- ENSG00000130766
- ENST00000645231
- ENSP00000496365
- ENSG00000285069
- Hi95
- SEST2
- HI95
- SES2
- SEST2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.82 | ||
biological process | 0.79 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.73 | ||
disease | 0.72 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.5 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 235 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.5 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 235 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (8)
Reactome (5)
KEGG (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | TP53 Regulates Metabolic Genes | ||||
Reactome | Transcriptional Regulation by TP53 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
TP53 Regulates Metabolic Genes | ||||
Transcriptional Regulation by TP53 | ||||
Gene Ontology Terms (38)
Functions (4)
Components (6)
Processes (28)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (102)
1 – 10 of 102
DHX57
Family: Enzyme
Novelty: 1.71428571
p_int: 0.999995958
p_ni: 0.000003725
p_wrong: 3.17e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
WDR5
Novelty: 0.00689807
p_int: 0.999992109
p_ni: 0.000007882
p_wrong: 9e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
SEC13
Novelty: 0.0100577
p_int: 0.999834631
p_ni: 0.000133122
p_wrong: 0.000032247
Score: 0.902
Data Source: BioPlex,STRINGDB
WDR24
Novelty: 1.44736842
Score: 0.999
Data Source: STRINGDB
MIOS
Novelty: 0.03378873
Score: 0.999
Data Source: STRINGDB
WDR59
Novelty: 0.27755881
Score: 0.999
Data Source: STRINGDB
NPRL2
Family: Enzyme
Novelty: 0.04015797
Score: 0.997
Data Source: Reactome,STRINGDB
NPRL3
Family: Enzyme
Novelty: 0.00771433
Score: 0.997
Data Source: Reactome,STRINGDB
SZT2
Novelty: 0.10810811
Score: 0.994
Data Source: Reactome,STRINGDB
PRDX1
Novelty: 0.00234504
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 173.50
PubMed score by year
PubTator Score 72.15
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEAL
1-70
MSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTG
70-140
GDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSF
140-210
VFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQ
210-280
EEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYS
280-350
LIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERN
350-420
LKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
420-480
MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
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