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Tclin
KCNK10
Potassium channel subfamily K member 10

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312350
  • ENSP00000310568
  • ENSG00000100433
  • ENST00000319231
  • ENSP00000312811
  • ENST00000340700
  • ENSP00000343104

Symbol
  • TREK2
  • TREK2
  • TREK-2
  • K2p10.1
  • PPP1R97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
molecular function
0.79
microRNA
0.75
phenotype
0.72
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Active Ligands (1)
1 – 1 of 1
CHEMBL1417584
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 10
VGNC:12812
736753
Macaque
potassium two pore domain channel subfamily K member 10
694669
Mouse
MGI:1919508
72258
Rat
RGD:619732
65272
Dog
potassium two pore domain channel subfamily K member 10
VGNC:42270
490822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 10
Macaque
potassium two pore domain channel subfamily K member 10
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 10
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57789-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (31)
1 – 10 of 31
KCNK2
Tclin
Family: IC
Novelty: 0.00315107
Score: 0.808
Data Source: Reactome,STRINGDB
SLC24A3
Tbio
Family: Transporter
Novelty: 0.05923224
Score: 0.647
Data Source: STRINGDB
KCNH6
Tclin
Family: IC
Novelty: 0.01126636
Score: 0.61
Data Source: STRINGDB
KCNJ10
Tbio
Family: IC
Novelty: 0.00273462
Score: 0.529
Data Source: STRINGDB
KCNJ16
Tbio
Family: IC
Novelty: 0.01883834
Score: 0.504
Data Source: STRINGDB
EML5
Tdark
Novelty: 0.29826509
Score: 0.499
Data Source: STRINGDB
GPR65
Tbio
Family: GPCR
Novelty: 0.02341854
Score: 0.48
Data Source: STRINGDB
EFCAB11
Tdark
Novelty: 0.68998855
Score: 0.479
Data Source: STRINGDB
KCNRG
Tbio
Novelty: 0.09992793
Score: 0.473
Data Source: STRINGDB
PTPN21
Tbio
Family: Enzyme
Novelty: 0.07773004
Score: 0.473
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.34

PubMed score by year
PubTator Score  41.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer