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Tbio
GJA9
Gap junction alpha-9 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357771
  • ENSP00000350415
  • ENSG00000131233
  • ENST00000360786
  • ENSP00000354020

Symbol
  • GJA10
  • CX58
  • CX59
  • GJA10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.53
tissue sample
0.49
cell type or tissue
0.48
small molecule perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
ZIK1
Tdark
Family:  TF
Novelty:  0.20771106
Score:  0.549
Data Source:  STRINGDB
ARHGEF10
Tbio
Novelty:  0.04928387
Score:  0.481
Data Source:  STRINGDB
FAXC
Tdark
Novelty:  0.42430855
Score:  0.476
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.459
Data Source:  STRINGDB
SLC35F5
Tdark
Family:  Transporter
Novelty:  0.53360993
Score:  0.455
Data Source:  STRINGDB
NAPEPLD
Tbio
Family:  Enzyme
Novelty:  0.00755191
Score:  0.433
Data Source:  STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.432
Data Source:  STRINGDB
GJD4
Tdark
Novelty:  0.40281374
Score:  0.432
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.424
Data Source:  STRINGDB
GJD2
Tbio
Novelty:  0.00263903
Score:  0.422
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
73.5
mathematical ability
3
2
3
51.7
myeloid white cell count
1
1
1
21.2
triglyceride measurement
1
1
1
17.8
leukocyte count
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
73.5
mathematical ability
3
51.7
myeloid white cell count
1
21.2
triglyceride measurement
1
17.8
leukocyte count
1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gap junction protein alpha 9
VGNC:1248
100609944
Macaque
gap junction protein alpha 9
715648
Dog
gap junction protein alpha 9
VGNC:54209
100684742
Horse
gap junction protein alpha 9
VGNC:50697
100054422
Cow
gap junction protein alpha 9
100848695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gap junction protein alpha 9
Macaque
gap junction protein alpha 9
Dog
gap junction protein alpha 9
Horse
gap junction protein alpha 9
Cow
gap junction protein alpha 9
Publication Statistics
PubMed Score 5.64
PubMed score by year
PubTator Score 2.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title