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Tbio
EEFSEC
Selenocysteine-specific elongation factor

Protein Classes
Protein Summary
Description
Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254730
  • ENSP00000254730
  • ENSG00000132394
  • ENST00000644579
  • ENSP00000494933
  • ENSG00000284869

Symbol
  • SELB
  • SELB
  • EFSEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.86
transcription factor binding site profile
0.82
interacting protein
0.75
gene perturbation
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.29   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.29   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
2
1
0
1.1
96.7
1
1
0
1.6
83.9
2
1
0
1.2
75.8
FEV/FEC ratio
1
1
1
69.2
parental genotype effect measurement
1
1
0
1.2
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
96.7
0
1.6
83.9
0
1.2
75.8
FEV/FEC ratio
1
69.2
parental genotype effect measurement
0
1.2
68.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic elongation factor, selenocysteine-tRNA specific
VGNC:10477
460671
Macaque
eukaryotic elongation factor, selenocysteine-tRNA specific
705784
Mouse
MGI:2137092
65967
Rat
RGD:1560552
500255
Dog
eukaryotic elongation factor, selenocysteine-tRNA specific
VGNC:40211
476514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic elongation factor, selenocysteine-tRNA specific
Macaque
eukaryotic elongation factor, selenocysteine-tRNA specific
Mouse
Rat
Dog
eukaryotic elongation factor, selenocysteine-tRNA specific
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57772-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Selenoamino acid metabolism
Reactome
Selenocysteine synthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Selenoamino acid metabolism
Selenocysteine synthesis
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (206)
1 – 10 of 206
SECISBP2
Tbio
Novelty: 0.00678361
Score: 0.997
Data Source: Reactome,STRINGDB
RPS3
Tbio
Novelty: 0.003106
Score: 0.986
Data Source: STRINGDB
RPL30
Tbio
Novelty: 0.0134194
Score: 0.98
Data Source: STRINGDB
RPS6
Tbio
Novelty: 0.00122241
Score: 0.972
Data Source: STRINGDB
RPS20
Tbio
Novelty: 0.01018837
Score: 0.968
Data Source: STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
Score: 0.967
Data Source: STRINGDB
RPS28
Tbio
Novelty: 0.03303065
Score: 0.966
Data Source: STRINGDB
RPS11
Tbio
Novelty: 0.0168881
Score: 0.966
Data Source: STRINGDB
RPS25
Tbio
Novelty: 0.02812798
Score: 0.965
Data Source: STRINGDB
RPS7
Tbio
Novelty: 0.00745987
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  116.29

PubMed score by year
PubTator Score  29.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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