Tbio RGS8 Regulator of G-protein signaling 8

Protein Summary

Description

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P57771
• B4DGL9
• Q3SYD2
• RGS8

Gene Name

• RGS8

Ensembl ID

• ENST00000258302
• ENSP00000258302
• ENSG00000135824
• ENST00000367556
• ENSP00000356527
• ENST00000367557
• ENSP00000356528
• ENST00000483095
• ENSP00000426289

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
trait	0.75
tissue sample	0.64
PubMedID	0.58
disease	0.55

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 8

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0