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Tbio
GSDMD
Gasdermin-D

Protein Summary
Description
Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-term ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262580
  • ENSP00000262580
  • ENSG00000104518
  • ENST00000526406
  • ENSP00000433209
  • ENST00000615119
  • ENSP00000482096
  • ENSG00000278718
  • ENST00000631751
  • ENSP00000488012

Symbol
  • DFNA5L
  • GSDMDC1
  • DF5L
  • DFNA5L
  • FKSG10
  • GSDMDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
kinase perturbation
0.76
transcription factor
0.66
tissue
0.61
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.03   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.03   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
94.6
Oral ulcer
1
1
0
1.1
94.6
C-reactive protein measurement
1
1
1
91.2
C-reactive protein measurement
1
1
1
91.2
monocyte count
1
1
1
59.8
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
94.6
Oral ulcer
0
1.1
94.6
C-reactive protein measurement
1
91.2
C-reactive protein measurement
1
91.2
monocyte count
1
59.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gasdermin D
VGNC:12194
739712
Macaque
gasdermin D
697137
Mouse
MGI:1916396
69146
Rat
RGD:1307261
315084
Dog
gasdermin D
VGNC:41526
609395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gasdermin D
Macaque
gasdermin D
Mouse
Rat
Dog
gasdermin D
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57764-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (110)
1 – 10 of 110
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.959
Data Source: STRINGDB
CASP4
Tchem
Family: Enzyme
Novelty: 0.00461865
Score: 0.944
Data Source: STRINGDB
CASP5
Tchem
Family: Enzyme
Novelty: 0.00734661
Score: 0.942
Data Source: STRINGDB
NLRP3
Tchem
Novelty: 0.00043957
Score: 0.937
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.916
Data Source: STRINGDB
FLG2
Tbio
Novelty: 0.03211244
Score: 0.912
Data Source: STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.91
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.91
Data Source: STRINGDB
CTSS
Tchem
Family: Enzyme
Novelty: 0.00786042
Score: 0.907
Data Source: STRINGDB
LYZ
Tbio
Family: Enzyme
Novelty: 0.00151342
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.03

PubMed score by year
PubTator Score  37.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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