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Tbio
NUP107
Nuclear pore complex protein Nup107

Protein Summary
Description
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229179
  • ENSP00000229179
  • ENSG00000111581
  • ENST00000378905
  • ENSP00000368185
  • ENST00000539906
  • ENSP00000441448

Symbol
  • ODG6
  • NUP84
  • NPHS11
  • ODG6; GAMOS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.92
interacting protein
0.86
transcription factor binding site profile
0.85
virus perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
NUP133
Tbio
Novelty:  0.02115225
p_int:  0.999915315
p_ni:  0.000084685
Score:  0.999
Data Source:  BioPlex,STRINGDB
NUP43
Tbio
Novelty:  0.11571309
p_int:  0.999534073
p_ni:  0.000465927
Score:  0.999
Data Source:  BioPlex,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.994727548
p_ni:  0.005272452
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPAST
Tbio
Novelty:  0.00303236
p_int:  0.986719872
p_ni:  0.013280128
Score:  0.705
Data Source:  BioPlex,STRINGDB
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.835211247
p_ni:  0.164788753
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.790388368
p_ni:  0.209611632
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.75971839
p_ni:  0.24028161
Data Source:  BioPlex
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.999
Data Source:  STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
Score:  0.999
Data Source:  STRINGDB
NUP160
Tbio
Novelty:  0.03667026
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (83)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
44.2
mean reticulocyte volume
1
1
1
29
red blood cell density measurement
1
1
1
21.4
mean corpuscular volume
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
44.2
mean reticulocyte volume
1
29
red blood cell density measurement
1
21.4
mean corpuscular volume
1
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 107
VGNC:5513
467062
Macaque
nucleoporin 107
718214
Mouse
MGI:2143854
103468
Rat
RGD:621160
116555
Dog
nucleoporin 107
VGNC:44044
474440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 107
Macaque
nucleoporin 107
Mouse
Rat
Dog
nucleoporin 107
Publication Statistics
PubMed Score 54.20
PubMed score by year
PubTator Score 38.53
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title