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Tbio
CLDN2
Claudin-2

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336803
  • ENSP00000336571
  • ENSG00000165376
  • ENST00000540876
  • ENSP00000443230
  • ENST00000541806
  • ENSP00000441283
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
tissue sample
0.69
transcription factor
0.66
tissue
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.11   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.11   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
7
0
2.2
95.3
1
1
0
1.4
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.2
95.3
0
1.4
35
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
claudin 2 [Source:HGNC Symbol;Acc:HGNC:2041]
Mouse
MGI:1276110
12738
Rat
RGD:1560247
300920
Dog
claudin 2
VGNC:39316
403649
Horse
claudin 2
VGNC:16591
100054776
Species
Name
OMA
EggNOG
Inparanoid
Macaque
claudin 2 [Source:HGNC Symbol;Acc:HGNC:2041]
Mouse
Rat
Dog
claudin 2
Horse
claudin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57739-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (69)
1 – 10 of 69
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.977
Data Source:  STRINGDB
OCLN
Tbio
Novelty:  0.00047671
Score:  0.944
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.934
Data Source:  STRINGDB
CLDN16
Tbio
Novelty:  0.0092505
Score:  0.926
Data Source:  STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.917
Data Source:  STRINGDB
CLDN11
Tbio
Novelty:  0.00275436
Score:  0.917
Data Source:  STRINGDB
CLDN15
Tbio
Novelty:  0.02763602
Score:  0.916
Data Source:  STRINGDB
CLDN18
Tbio
Novelty:  0.01299528
Score:  0.914
Data Source:  STRINGDB
CLDN1
Tbio
Novelty:  0.00505039
Score:  0.914
Data Source:  STRINGDB
CLDN10
Tbio
Novelty:  0.02175843
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  350.11

PubMed score by year
PubTator Score  150.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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