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Tbio
RAB25
Ras-related protein Rab-25

Protein Summary
Description
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361084
  • ENSP00000354376
  • ENSG00000132698

Symbol
  • CATX8
  • CATX-8
  • RAB11C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
interacting protein
0.72
cellular component
0.71
protein domain
0.58
biological process
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.2   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.2   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
69.5
apolipoprotein A 1 measurement
1
1
1
10
high density lipoprotein cholesterol measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
69.5
apolipoprotein A 1 measurement
1
10
high density lipoprotein cholesterol measurement
1
7.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB25, member RAS oncogene family
VGNC:9893
457382
Macaque
RAB25, member RAS oncogene family
718131
Mouse
MGI:1858203
53868
Rat
RGD:1308447
310632
Dog
RAB25, member RAS oncogene family
VGNC:45265
490418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB25, member RAS oncogene family
Macaque
RAB25, member RAS oncogene family
Mouse
Rat
Dog
RAB25, member RAS oncogene family
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (149)
1 – 10 of 149
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
p_int: 0.999999784
p_wrong: 2.15e-7
Score: 0.919
Data Source: BioPlex,STRINGDB
RAB11B
Tbio
Family: Enzyme
Novelty: 0.00557558
p_int: 0.999983683
p_ni: 0.00000568
p_wrong: 0.000010637
Score: 0.922
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.99716976
p_ni: 0.002830229
p_wrong: 1.2e-8
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.966146614
p_ni: 0.033851854
p_wrong: 0.000001532
Score: 0.212
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.963425703
p_ni: 0.036454869
p_wrong: 0.000119428
Score: 0.162
Data Source: BioPlex,STRINGDB
RAB11FIP2
Tbio
Novelty: 0.06330621
Score: 0.994
Data Source: STRINGDB
RABGGTA
Tdark
Family: Enzyme
Novelty: 0.19962321
Score: 0.936
Data Source: STRINGDB
RAB34
Tbio
Novelty: 0.03645677
Score: 0.934
Data Source: STRINGDB
RAB34
Tbio
Family: Enzyme
Novelty: 0.03645677
Score: 0.934
Data Source: STRINGDB
RAB36
Tbio
Family: Enzyme
Novelty: 0.14109545
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.20

PubMed score by year
PubTator Score  56.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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