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Tbio
CARD18
Caspase recruitment domain-containing protein 18

Protein Summary
Description
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530950
  • ENSP00000436691
  • ENSG00000255501

Symbol
  • ICEBERG
  • ICEBERG
  • UNQ5804
  • pseudo-ICE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
cell line
0.68
microRNA
0.67
chemical
0.41
phenotype
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
1
68.6
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase recruitment domain family member 18
705678
Opossum
caspase recruitment domain-containing protein 18-like
103093159
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase recruitment domain family member 18
Opossum
caspase recruitment domain-containing protein 18-like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57730-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (19)
1 – 10 of 19
CARD17
Tbio
Family:  Enzyme
Novelty:  0.50566454
Score:  0.877
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.874
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.836
Data Source:  STRINGDB
CARD16
Tbio
Family:  Enzyme
Novelty:  0.00158016
Score:  0.807
Data Source:  STRINGDB
ANKRD20A3
Tdark
Novelty:  22
Score:  0.681
Data Source:  STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
Score:  0.662
Data Source:  STRINGDB
ANKRD20A1
Tdark
Novelty:  1.25669657
Score:  0.58
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.535
Data Source:  STRINGDB
CASP5
Tchem
Family:  Enzyme
Novelty:  0.00734661
Score:  0.499
Data Source:  STRINGDB
CARD6
Tbio
Family:  Enzyme
Novelty:  0.08868556
Score:  0.471
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.73

PubMed score by year
PubTator Score  10.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer