Tbio TMPRSS3 Transmembrane protease serine 3

Protein Summary

Description

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P57727
• D3DSJ6
• Q5USC7
• Q6ZMC3

Gene Name

• TMPRSS3

Ensembl ID

• ENST00000291532
• ENSP00000291532
• ENSG00000160183
• ENST00000398397
• ENSP00000381434
• ENST00000433957
• ENSP00000411013
• ENST00000644384
• ENSP00000494414

Symbol

• ECHOS1
• TADG12
• DFNB8
• DFNB10
• ECHOS1
• TADG12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
microRNA	0.81
gene perturbation	0.58
molecular function	0.56
cellular component	0.55

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Transmembrane Protease Serine 3

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Transmembrane Protease Serine 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.33   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.33   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0