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Tbio
GEMIN4
Gem-associated protein 4

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319004
  • ENSP00000321706
  • ENSG00000179409

Symbol
  • p97
  • HC56
  • HCAP1
  • HHRF-1
  • NEDMCR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
drug perturbation
0.87
cellular component
0.85
interacting protein
0.82
histone modification site profile
0.79


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.92   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.92   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 4
VGNC:12155
454403
Macaque
gem nuclear organelle associated protein 4
699841
Mouse
MGI:2449313
276919
Rat
RGD:1563715
497958
Dog
gem nuclear organelle associated protein 4
VGNC:41174
611189
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 4
Macaque
gem nuclear organelle associated protein 4
Mouse
Rat
Dog
gem nuclear organelle associated protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P57678-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (14)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (113)
1 – 10 of 113
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.999861476
p_ni: 0.000138524
Score: 0.731
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.999789508
p_ni: 0.000210492
Score: 0.998
Data Source: BioPlex,STRINGDB
GEMIN7
Tbio
Novelty: 0.04835353
p_int: 0.999725083
p_ni: 0.000274917
Score: 0.986
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.994031487
p_ni: 0.005968513
Score: 0.96
Data Source: BioPlex,STRINGDB
GEMIN6
Tbio
Novelty: 0.02104816
p_int: 0.989759863
p_ni: 0.010240137
Score: 0.998
Data Source: BioPlex,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.985844717
p_ni: 0.014155283
Score: 0.992
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.979522631
p_ni: 0.020477369
Score: 0.942
Data Source: BioPlex,STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.976192561
p_ni: 0.023807439
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.967833742
p_ni: 0.032166258
Data Source: BioPlex
GEMIN2
Tbio
Novelty: 0.02072868
p_int: 0.962655142
p_ni: 0.037344858
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.92

PubMed score by year
PubTator Score  27.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer