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Tbio
SYNJ2BP
Synaptojanin-2-binding protein

Protein Summary
Description
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256366
  • ENSP00000256366
  • ENSG00000213463

Symbol
  • OMP25
  • ARIP2
  • OMP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
interacting protein
0.95
kinase perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
39.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
39.9
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
synaptojanin 2 binding protein
100049833
Anole lizard
synaptojanin 2 binding protein
103277510
Species
Name
OMA
EggNOG
Inparanoid
Horse
synaptojanin 2 binding protein
Anole lizard
synaptojanin 2 binding protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57105-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
RRBP1
Tbio
Novelty: 0.01494613
p_int: 0.999802131
p_ni: 0.000197869
Score: 0.404
Data Source: BioPlex,STRINGDB
TSC22D3
Tbio
Family: TF
Novelty: 0.00660285
p_int: 0.999498014
p_ni: 0.000493256
p_wrong: 0.000008731
Data Source: BioPlex
TSC22D1
Tbio
Family: TF
Novelty: 0.01934962
p_int: 0.995911486
p_ni: 0.002979861
p_wrong: 0.001108652
Data Source: BioPlex
OTULIN
Tbio
Family: Enzyme
Novelty: 0.04694238
p_int: 0.99017718
p_ni: 0.008909154
p_wrong: 0.000913666
Data Source: BioPlex
ESYT1
Tbio
Novelty: 0.03069611
p_int: 0.982559476
p_ni: 0.017440524
Score: 0.488
Data Source: BioPlex,STRINGDB
AKAP14
Tbio
Family: Enzyme
Novelty: 0.50699923
p_int: 0.94258671
p_ni: 0.05741329
Score: 0.527
Data Source: BioPlex,STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
p_int: 0.940796852
p_ni: 0.059203148
Data Source: BioPlex
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.930529511
p_ni: 0.069470489
Data Source: BioPlex
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
p_int: 0.909413908
p_ni: 0.090586054
p_wrong: 3.8e-8
Data Source: BioPlex
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
p_int: 0.891084899
p_ni: 0.108915101
Data Source: BioPlex
Publication Statistics
PubMed Score  44.65

PubMed score by year
PubTator Score  19.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer