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Tbio
JAM2
Junctional adhesion molecule B

Protein Summary
Description
May play a role in the processes of lymphocyte homing to secondary lymphoid organs. This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312957
  • ENSP00000318416
  • ENSG00000154721
  • ENST00000400532
  • ENSP00000383376
  • ENST00000480456
  • ENSP00000420419

Symbol
  • C21orf43
  • VEJAM
  • JAMB
  • CD322
  • JAM-B
  • VEJAM
  • PRO245
  • VE-JAM
  • C21orf43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
protein domain
0.85
transcription factor perturbation
0.8
transcription factor binding site profile
0.71
histone modification site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0