Tbio WDR4 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Protein Summary

Description

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P57081
• A8KA58
• B2RCA3
• B4DNQ7
• D3DSK3
• Q9BVM5
• Q9HCR3

Gene Name

• WDR4

Ensembl ID

• ENST00000330317
• ENSP00000328671
• ENSG00000160193
• ENST00000398208
• ENSP00000381266

Symbol

• MIGSB
• TRM82
• GAMOS6
• TRMT82

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.9
small molecule perturbation	0.83
cell type or tissue	0.79
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Trna (Guanine-n(7)-)-methyltransferase Non-catalytic Subunit Wdr4

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Trna (Guanine-n(7)-)-methyltransferase Non-catalytic Subunit Wdr4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.13   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.13   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0