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Tbio
WDR4
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Protein Summary
Description
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330317
  • ENSP00000328671
  • ENSG00000160193
  • ENST00000398208
  • ENSP00000381266

Symbol
  • MIGSB
  • TRM82
  • GAMOS6
  • TRMT82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.9
small molecule perturbation
0.83
cell type or tissue
0.79
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 4
VGNC:1113
458584
Mouse
MGI:1889002
57773
Rat
RGD:1585179
690032
Dog
WD repeat domain 4
VGNC:48365
487783
Horse
WD repeat domain 4
VGNC:24996
100057729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 4
Mouse
Rat
Dog
WD repeat domain 4
Horse
WD repeat domain 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P57081-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (194)
1 – 10 of 194
METTL1
Tbio
Family: Enzyme
Novelty: 0.03641249
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ALG12
Tbio
Family: Enzyme
Novelty: 0.03785588
p_int: 0.9548395
p_ni: 0.00064984
p_wrong: 0.04451066
Score: 0.261
Data Source: BioPlex,STRINGDB
RBM14
Tbio
Novelty: 0.01286049
p_int: 0.928025113
p_ni: 0.071934527
p_wrong: 0.00004036
Data Source: BioPlex
RNF138
Tbio
Family: TF
Novelty: 0.07543428
p_int: 0.899353367
p_ni: 0.100646633
Score: 0.175
Data Source: BioPlex,STRINGDB
PBX2
Tbio
Family: TF
Novelty: 0.01339291
p_int: 0.893793513
p_ni: 0.106206487
Score: 0.175
Data Source: BioPlex,STRINGDB
XPNPEP1
Tchem
Family: Enzyme
Novelty: 0.00345088
p_int: 0.888266564
p_ni: 0.111477151
p_wrong: 0.000256285
Score: 0.357
Data Source: BioPlex,STRINGDB
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.884738413
p_ni: 0.115261587
Data Source: BioPlex
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.835434211
p_ni: 0.164565789
Score: 0.246
Data Source: BioPlex,STRINGDB
TRMT61A
Tbio
Family: Enzyme
Novelty: 0.04443394
Score: 0.954
Data Source: STRINGDB
TRMT6
Tbio
Family: Enzyme
Novelty: 0.06718902
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.35

PubMed score by year
PubTator Score  6.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer